1
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: not found

      Fragile sites on human chromosomes: demonstration of their dependence on the type of tissue culture medium.

      Science (New York, N.Y.)
      Cells, Cultured, ultrastructure, Chromosome Aberrations, genetics, Chromosome Disorders, Chromosomes, Human, 1-3, Chromosomes, Human, 19-20, Chromosomes, Human, 6-12 and X, Culture Media, Fibroblasts, Humans, Intellectual Disability, Lymphocytes, Sex Chromosomes

      Read this article at

      ScienceOpenPublisherPubMed
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          The observation of heritable fragile sites on human chromosomes prepared for lymphocyte cultures has been shown to depend on the type of tissue culture medium in which the lymphocytes are grown. The sites are observed at a much greater frequency when medium 199 is used than when RPMI 1640, Ham's F10, Eagle's (basal), and CMRL 1969 are used. One site on the X chromosome is of clinical significance in that it is a marker for X-linked mental retardation.

          Related collections

          Author and article information

          Comments

          Comment on this article