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      Effect of Adenosine on Adrenergic Neurotransmission in the Superfused Rat Portal Vein

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          This study examined the effect of exogenously applied adenosine on the release of <sup>3</sup>H-norepinephrine from the field-stimulated, superfused rat portal vein. Adenosine was found to inhibit the field-stimulated release of <sup>3</sup>H-norepinephrine in a dose-dependent manner in 50- to 1,000- µM concentrations. The effect was reversed when adenosine was washed out. The inhibitory effects of adenosine were antagonized by theophylline (10<sup>–4</sup> M) which by itself showed a slight enhancement of stimulated <sup>3</sup>H-norepinephrine release. ATP was found to inhibit <sup>3</sup>H-norepinephrine release at the same concentration as adenosine while inosine was inactive. When adenosine was tested in the presence of the muscarinic and α-adrenergic blocking agents atropine and phenoxybenzamine along with indomethacin, a prostaglandin synthesis inhibitor, its inhibitory effect on the stimulated release of <sup>3</sup>H-norepinephrine persisted. It is concluded that adenosine and/or ATP can modulate the nerve-stimulated induced release of norepinephrine presumably by an action on the adrenergic nerve terminals.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          19 September 2008
          : 16
          : 6
          : 302-310
          Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, Va.
          158220 Blood Vessels 1979;16:302–310
          © 1979 S. Karger AG, Basel

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          Pages: 9
          Original Paper


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