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Bisphenol A (BPA) and nonylphenol (NP) were treated with manganese peroxidase (MnP)
and laccase prepared from the culture of lignin-degrading fungi. Laccase in the presence
of 1-hydroxybenzotriazole (HBT), the so-called laccase-mediator system, was also applied
to remove the estrogenic activity. Both chemicals disappeared in the reaction mixture
within a 1-h treatment with MnP but the estrogenic activities of BPA and NP still
remained 40% and 60% in the reaction mixtures after a 1-h and a 3-h treatment, respectively.
Extension of the treatment time to 12 h completed the removal of estrogenic activities
of BPA and NP. The laccase has less ability to remove these activities than MnP, but
the laccase-HBT system was able to remove the activities in 6 h. A gel permeation
chromatography (GPC) analysis revealed that main reaction products of BPA and NP may
be oligomers formed by the action of enzymes. Enzymatic treatments extended to 48
h did not regenerate the estrogenic activities, suggesting that the ligninolytic enzymes
are effective for the removal of the estrogenic activities of BPA and NP.