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      An intravascular immune response to Borrelia burgdorferi involves Kupffer cells and iNKT cells

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          Abstract

          Here we investigate the dynamics of the hepatic intravascular immune response to a pathogen relevant to invariant natural killer T cells ( iNKT cells). Immobilized Kupffer cells with highly ramified extended processes into multiple sinusoids could effectively capture blood-borne, disseminating Borrelia burgdorferi, creating a highly efficient surveillance and filtering system. After ingesting B. burgdorferi, Kupffer cells induced chemokine receptor CXCR3–dependent clustering of iNKT cells. Kupffer cells and iNKT cells formed stable contacts via the antigen-presenting molecule CD1d, which led to iNKT cell activation. An absence of iNKT cells caused B. burgdorferi to leave the blood and enter the joints more effectively. B. burgdorferi that escaped Kupffer cells entered the liver parenchyma and survived despite Ito cell responses. Kupffer cell– iNKT cell interactions induced a key intravascular immune response that diminished the dissemination of B. burgdorferi.

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          Author and article information

          Journal
          100941354
          21750
          Nat Immunol
          Nat. Immunol.
          Nature immunology
          1529-2908
          1529-2916
          14 November 2016
          14 March 2010
          April 2010
          17 November 2016
          : 11
          : 4
          : 295-302
          Affiliations
          [1 ]Department of Physiology & Pharmacology, University of Calgary, Alberta, Canada
          [2 ]Department of Biochemistry & Molecular Biology, University of Calgary, Alberta, Canada
          [3 ]Department of Microbiology and Infectious Diseases, University of Calgary, Alberta, Canada
          [4 ]Department of Medicine, University of Virginia, Charlottesville, Virginia, USA
          [5 ]Department of Molecular Cell Biology, Free University, Amsterdam, The Netherlands
          Author notes
          Correspondence should be addressed to P.K. ( pkubes@ 123456ucalgary.ca )
          Article
          PMC5114121 PMC5114121 5114121 capmc2458
          10.1038/ni.1855
          5114121
          20228796
          8e1989d6-b4ba-4ef6-85e0-c58f13d250e3

          Reprints and permissions information is available online at http://npg.nature.com/reprintsandpermissions/.

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