We have investigated the spatial distribution, and the properties and chemical composition of the dust orbiting HD 100546. This system is remarkably different from other isolated Herbig Ae/Be stars in both the strength of the mid-IR excess and the composition of the circumstellar dust. We speculate that the formation and spatial distribution of the crystalline dust observed in the HD 100546 system may be linked to the formation of a proto-Jupiter in the disk around HD 100546. Such a proto-Jupiter could gravitationally stir the disk leading to a collisional cascade of asteroidal sized objects producing small crystalline grains, or it could cause shocks by tidal interaction with the disk which might produce crystalline dust grains through flash heating. As shown by Malfait et al. (1998), the infrared spectrum of HD 100546 is very similar to that of C/1995 O1 Hale-Bopp (Crovisier et al. 1997). Using an identical methodology, we have therefore also studied this solar system comet. Both objects have an almost identical grain composition, but with the important difference that the individual dust species in Hale-Bopp are in thermal contact with each other, while this is not the case in HD 100546. This suggests that if similar processes leading to the dust composition as seen in HD 100546 also occurred in our own solar system, that Hale-Bopp formed after the formation of one or more proto-gas giants.