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Neglected Tropical Disease Control in the “Post-American World”

1 , 2 , *

PLoS Neglected Tropical Diseases

Public Library of Science

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      Most cited references 15

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      Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

      The neglected tropical diseases (NTDs) are the most common conditions affecting the poorest 500 million people living in sub-Saharan Africa (SSA), and together produce a burden of disease that may be equivalent to up to one-half of SSA's malaria disease burden and more than double that caused by tuberculosis. Approximately 85% of the NTD disease burden results from helminth infections. Hookworm infection occurs in almost half of SSA's poorest people, including 40–50 million school-aged children and 7 million pregnant women in whom it is a leading cause of anemia. Schistosomiasis is the second most prevalent NTD after hookworm (192 million cases), accounting for 93% of the world's number of cases and possibly associated with increased horizontal transmission of HIV/AIDS. Lymphatic filariasis (46–51 million cases) and onchocerciasis (37 million cases) are also widespread in SSA, each disease representing a significant cause of disability and reduction in the region's agricultural productivity. There is a dearth of information on Africa's non-helminth NTDs. The protozoan infections, human African trypanosomiasis and visceral leishmaniasis, affect almost 100,000 people, primarily in areas of conflict in SSA where they cause high mortality, and where trachoma is the most prevalent bacterial NTD (30 million cases). However, there are little or no data on some very important protozoan infections, e.g., amebiasis and toxoplasmosis; bacterial infections, e.g., typhoid fever and non-typhoidal salmonellosis, the tick-borne bacterial zoonoses, and non-tuberculosis mycobaterial infections; and arboviral infections. Thus, the overall burden of Africa's NTDs may be severely underestimated. A full assessment is an important step for disease control priorities, particularly in Nigeria and the Democratic Republic of Congo, where the greatest number of NTDs may occur.
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        Rescuing the bottom billion through control of neglected tropical diseases.

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          The Global Health System: Strengthening National Health Systems as the Next Step for Global Progress

           Julio J Frenk (2010)
          In the second in a series of articles on the changing nature of global health institutions, Julio Frenk offers a framework to better understand national health systems and their role in global health.

            Author and article information

            [1 ]Department of Microbiology, Immunology, and Tropical Medicine, George Washington University, Washington, D.C., United States of America
            [2 ]Sabin Vaccine Institute, Washington, D.C., United States of America
            Swiss Tropical and Public Health Institute, Switzerland
            Author notes

            Author Information: PJH is Editor-in-Chief of PLoS Neglected Tropical Diseases. He is Distinguished Research Professor at George Washington University, and President of the Sabin Vaccine Institute. Some of the content in this article was delivered in his commencement speech to the 2010 graduating class of the George Washington University School of Medicine and Health Sciences.

            Role: Editor
            PLoS Negl Trop Dis
            PLoS Neglected Tropical Diseases
            Public Library of Science (San Francisco, USA )
            August 2010
            31 August 2010
            : 4
            : 8
            Peter J. Hotez. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
            Pages: 4
            Public Health and Epidemiology/Global Health
            Public Health and Epidemiology/Health Policy

            Infectious disease & Microbiology


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