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      Clinical Evaluation of Succinylated Collagen Bandage Lenses for Ophthalmic Applications

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          Aim: To study whether succinylated collagen bandage lenses (SCBL) prepared from modified bovine collagen (succinylated collagen) can replace other bandage lenses presently employed to treat various corneal conditions like filamentary keratitis, dry eyes, recurrent corneal erosions, foreign body removal and epithelial trauma. Methods: This observational case study included 32 patients (22 female and 10 male): 8 patients for filamentary keratitis (25%), 10 patients for dry eyes (31%), 4 patients for recurrent corneal erosions (13%), 7 patients for foreign body removal (22%) and 3 patients for epithelial trauma (9%). Their eyes were evaluated for biocompatibility, in vivo transparency, patient comfort, corneal fit, best corrected visual acuity (BCVA), tear fluid level and dissolution rate of SCBL. This was carried out over a 24-hour period of time. Results: SCBL exhibited good transparency and remained transparent throughout the period of study (between 0 and 24 h) in the eyes of patients. SCBL did not cause any irritation, discomfort and foreign body sensation in the eye and eyes remained comfortable throughout the experiment. BCVA in the control group of patients was 1.00 (20/20). Mean (±SD) BCVA before inserting SCBL (in decimal equivalent) was 0.31 (20/60) ± 0.18 (range 0.1– 0.66). BCVA (±SD) changed to 0.25 (20/80) ± 0.18 4 h after the application of SCBL and 0.27 (20/70) ± 0.18 24 h after the application of SCBL, with a safety index of 1.20. The mean (±SD) tear fluid level before application of SCBL was 11.9 ± 5.39 h (range 3–24 mm) and changed to 13.9 ± 5.68 h (range 5–28 mm) after 4 h of application of SCBL and 15.9 ± 5.72 h (range 7–30 mm) after 24 h with a safety index of 13 mm. The mean (±SD) dissolution rate of SCBL in the control group of patients was 17.8 ± 8.65 h (range 10–24 h) and the mean (±SD) dissolution rate in the experimental group was 22.2 ± 9.29 h (range 10–24 h). We report the use of SCBL in various corneal conditions. Conclusion: The present study showed that SCBL has complete corneal fit and good comfort in human eyes. Transparency was maintained for a longer period along with fair visual acuity and improvement in tear fluid levels. The disadvantages of other bandage lenses presently used to treat various corneal conditions could be overcome by the use of SCBL lenses.

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          Most cited references 25

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          Collagen is regarded as one of the most useful biomaterials. The excellent biocompatibility and safety due to its biological characteristics, such as biodegradability and weak antigenecity, made collagen the primary resource in medical applications. The main applications of collagen as drug delivery systems are collagen shields in ophthalmology, sponges for burns/wounds, mini-pellets and tablets for protein delivery, gel formulation in combination with liposomes for sustained drug delivery, as controlling material for transdermal delivery, and nanoparticles for gene delivery and basic matrices for cell culture systems. It was also used for tissue engineering including skin replacement, bone substitutes, and artificial blood vessels and valves. This article reviews biomedical applications of collagen including the collagen film, which we have developed as a matrix system for evaluation of tissue calcification and for the embedding of a single cell suspension for tumorigenic study. The advantages and disadvantages of each system are also discussed.
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                Author and article information

                Ophthalmic Res
                Ophthalmic Research
                S. Karger AG
                August 2008
                25 April 2008
                : 40
                : 5
                : 257-266
                aBio-Products Laboratory, Central Leather Research Institute, Adyar, bDr. Agarwal Eye Hospital and Research Centre, and cDepartment of Ophthalmology, Government Royapettah Hospital, Chennai, India
                127833 Ophthalmic Res 2008;40:257–266
                © 2008 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 9, Tables: 3, References: 57, Pages: 10
                Original Paper


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