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SMARCD2 subunit of SWI/SNF chromatin-remodeling complexes mediates granulopoiesis through a CEBPɛ dependent mechanism
Pierre Priam ,
Veneta Krasteva ,
Philippe Rousseau ,
Giovanni D'Angelo ,
Louis Gaboury ,
Guy Sauvageau ,
Julie A Lessard
April 3 2017
April 3 2017
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Abstract
Julie Lessard and colleagues report that ATP-dependent SWI/SNF chromatin-remodeling complex subunit SMARCD2 is essential for granulocyte development. They find that Smarcd2-deficient mice fail to generate functioning neutrophils and eosinophils, and they determine that the divergent coiled-coil 1 and SWIB domains are responsible for functional specificity during granulocyte differentiation.