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      A Case of Acrodermatitis Enteropathica Localized on the Hands and Feet with a Normal Serum Zinc Level

      case-report

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          Abstract

          Acrodermatitis enteropathica is classified as a congenital autosomal recessive type and an acquired transient type. This disease manifests as acral and periorificial dermatitis, alopecia, intractable diarrhea, and failure to thrive. Whereas the autosomal hereditary type is caused by malabsorption of zinc in the intestine, the acquired type is caused by low nutritional support or decreased peripheral release of zinc from blood. We experienced a case of a 5-month old, breast feeding, full-term female presenting with only acral bullous dermatitis without diarrhea, periorificial dermatitis and an abnormal serum zinc level.

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          Most cited references10

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          Acrodermatitis enteropathica and an overview of zinc metabolism.

          Acrodermatitis enteropathica is a rare autosomal recessive disorder of zinc deficiency. The genetic defect has been mapped to 8q24 and the defective gene identified as SLC39A4, which encodes the zinc transporter Zip4. The diagnosis is made by way of clinical presentation together with histopathology and laboratory tests. Here we provide an overview of zinc metabolism and a description of inherited and acquired zinc deficiency.
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            Acrodermatitis enteropathica.

            P Aggett (1982)
            A brief review of the clinical and biochemical features of Acrodermatitis enteropathica is given. This condition in now known to be caused by a systemic zinc deficiency secondary to a defect in the intestinal absorption of zinc and it illustrates the metabolic importance of this element in man.
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              Acrodermatitis enteropathica without hypozincemia.

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                Author and article information

                Journal
                Ann Dermatol
                AD
                Annals of Dermatology
                Korean Dermatological Association; The Korean Society for Investigative Dermatology
                1013-9087
                2005-3894
                September 2011
                30 September 2011
                : 23
                : Suppl 1
                : S88-S90
                Affiliations
                Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea.
                Author notes
                Corresponding author: Eung Ho Choi, M.D., Department of Dermatology, Wonju Christian Hospital, 162 Ilsan-dong, Wonju 220-701, Korea. Tel: 82-33-741-0623, Fax: 82-33-748-2650, choieh@ 123456yonsei.ac.kr
                Article
                10.5021/ad.2011.23.S1.S88
                3199433
                22028583
                8e69a794-1092-48bf-9640-8bd97e2f9afc
                Copyright © 2011 Korean Dermatological Association; The Korean Society for Investigative Dermatology

                This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ( http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

                History
                : 04 November 2009
                : 23 December 2009
                : 08 October 2010
                Categories
                Case Report

                Dermatology
                acrodermatitis enteropathica,zinc,palmoplantar
                Dermatology
                acrodermatitis enteropathica, zinc, palmoplantar

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