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      NH2-terminal localization of that part of the staphylococcal enterotoxins polypeptide chain responsible for binding with membrane receptor and mitogenic effect.

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      The International journal of biochemistry

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          Abstract

          It is established that the part of the SEA and SEC2 polypeptide chain responsible for the binding of these toxin proteins with the membrane receptor on the surface of rabbit thymocytes and mitogenic effect is localised in the NH2-terminal region of the molecule. The SEC2 splits in two fragments T1 (17 kdalton) and T2 (12.5 kdalton) under limited proteolysis by trypsin in the presence of 2-ME. The amino acid terminal residues of SEA, SEC2 and their proteolytic fragments are also studied.

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          Author and article information

          Journal
          Int. J. Biochem.
          The International journal of biochemistry
          0020-711X
          0020-711X
          1986
          : 18
          : 5
          Article
          3486788

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