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      Association of a Deletion Polymorphism of the Angiotensin-Converting Enzyme Gene with Left-Ventricular Hypertrophy in Japanese Women with Essential Hypertension; Multicenter Study of 1,919 Subjects

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          The relationship of an insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme (ACE) gene to left-ventricular hypertrophy in individuals with essential hypertension (EH) was investigated in a large population of Japanese men and women. The ACE genotype of 762 subjects with EH (425 men and 337 women) and 1,157 healthy controls (604 men and 553 women) was determined by polymerase chain reaction analysis. The distribution of ACE genotypes did not differ significantly between patients with EH and control in both men and women. For women with EH, the DD genotype was positively associated with the thickness of the interventricular septum and inversely associated with the left ventricular end-diastolic dimension, both determined by echocardiography. In contrast, the DD genotype was not associated with any echocardiographic parameter in men with EH. These results indicate that the DD genotype is a risk factor for left-ventricular hypertrophy in Japanese women with EH, but not for Japanese men.

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          Author and article information

          S. Karger AG
          19 November 2008
          : 88
          : 4
          : 309-314
          aDaido Hospital, Nagoya, bDepartment of Clinical Laboratory Medicine, and cFirst Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, dMarine Clinic, Nagoya, eNagoya Daini Red Cross Hospital, Nagoya, fOkazaki City Hospital, Okazaki, sChita City Hospital, Chita, hToyota Memorial Hospital, Toyota, iTokai Central Hospital, Kagamihara, jNational Chubu Hospital, and Department of Geriatric Research, National Institute for Longevity Sciences, Obu, Japan
          177351 Cardiology 1997;88:309–314
          © 1997 S. Karger AG, Basel

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          Page count
          Pages: 6
          General Cardiology


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