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      Relationships between pH i and Tension in Isolated Rat Mesenteric Resistance Arteries

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      Journal of Vascular Research

      S. Karger AG

      pH, Arterial smooth muscle

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          Investigations into the relationship between pHi and tension were carried out in rat mesenteric resistance arteries. Acute acidosis, induced by ammonium chloride pre-pulse, led to variable and transient tension development, but simultaneous removal of extracellular sodium led to a sustained rise in tension associated with maintained intracellular acidification. Dependence of tension and pH<sub>i</sub> recovery from acute acidosis on Na/H exchange and anion exchange pathways was demonstrated using pharmacological inhibitors. Additionally, removal of HCO<sub>3</sub> suggested the anion pathway involved was Na-dependent HCO<sub>3</sub> transport. Removal of extracellular calcium, or pharmacological inhibition of voltage-dependent calcium channels, prevented the tension development in response to NH<sub>4</sub>Cl pre-pulse in an Na-free medium, but did not affect pH<sub>i</sub>. Intracellular acidosis resulting from elevation of the P<sub>CO2</sub>resulted in initial vasoconstriction followed by profound vasodilatation of arteries pre-contracted with noradrenaline (NA). The response to alkalosis induced by NH<sub>4</sub>C1 or by lowering the Pco<sub>2</sub> ted to initial dilatation followed by potentiation of NA-induced tension.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 29
          : 4
          : 330-340
          Division of Physiology, United Medical and Dental Schools’ Smooth Muscle Group, London, UK
          158948 J Vasc Res 1992;29:330–340
          © 1992 S. Karger AG, Basel

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          Page count
          Pages: 11
          Research Paper


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