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      Regulation of cytoplasmic mRNA decay.

      1 ,

      Nature reviews. Genetics

      Springer Nature

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          Abstract

          Discoveries made over the past 20 years highlight the importance of mRNA decay as a means of modulating gene expression and thereby protein production. Up until recently, studies largely focused on identifying cis-acting sequences that serve as mRNA stability or instability elements, the proteins that bind these elements, how the process of translation influences mRNA decay and the ribonucleases that catalyse decay. Now, current studies have begun to elucidate how the decay process is regulated. This Review examines our current understanding of how mammalian cell mRNA decay is controlled by different signalling pathways and lays out a framework for future research.

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          Author and article information

          Journal
          Nat. Rev. Genet.
          Nature reviews. Genetics
          Springer Nature
          1471-0064
          1471-0056
          Mar 06 2012
          : 13
          : 4
          Affiliations
          [1 ] Department of Molecular and Cellular Biochemistry and Center for RNA Biology, The Ohio State University, Columbus, Ohio 43210, USA. schoenberg.3@osu.edu
          Article
          nrg3160 NIHMS372995
          10.1038/nrg3160
          3351101
          22392217

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