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      Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression.

      Oncogene

      Animals, Cell Transformation, Neoplastic, Genes, Tumor Suppressor, Humans, I-kappa B Kinase, antagonists & inhibitors, NF-kappa B, physiology

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          Abstract

          Abundant data support a key role for the transcription factor nuclear factor-kappaB (NF-kappaB) signaling pathway in controlling the initiation and progression of human cancer. NF-kappaB and associated regulatory proteins such as IkappaB kinase (IKK) are activated downstream of many oncoproteins and there is much evidence for the activation of NF-kappaB-dependent target genes in a variety of solid tumors and hematologic malignancies. This review focuses on the mechanisms by which the NF-kappaB pathway is activated in cancer and on the oncogenic functions controlled by activated NF-kappaB. Additionally, the effects of NF-kappaB activation in tumors relative to cancer therapy are also discussed.

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          Journal
          17072330
          10.1038/sj.onc.1209942

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