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      Guidance for the identification of endocrine disruptors in the context of Regulations (EU) No 528/2012 and (EC) No 1107/2009

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          This Guidance describes how to perform hazard identification for endocrine‐disrupting properties by following the scientific criteria which are outlined in Commission Delegated Regulation ( EU) 2017/2100 and Commission Regulation ( EU) 2018/605 for biocidal products and plant protection products, respectively.

          Abstract

          This publication is linked to the following EFSA Supporting Publications article: http://onlinelibrary.wiley.com/doi/10.2903/sp.efsa.2018.EN-1447/full

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          Comparative molecular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins.

          Richard D. Cramer, David E Patterson, Jeffrey Bunce (1988)
          Article 0 comments Cited 345 times – based on 0 reviews     Review now
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            Overview of steroidogenic enzymes in the pathway from cholesterol to active steroid hormones.

            Anita Payne, Dale B Hales (2004)
            Significant advances have taken place in our knowledge of the enzymes involved in steroid hormone biosynthesis since the last comprehensive review in 1988. Major developments include the cloning, identification, and characterization of multiple isoforms of 3beta-hydroxysteroid dehydrogenase, which play a critical role in the biosynthesis of all steroid hormones and 17beta-hydroxysteroid dehydrogenase where specific isoforms are essential for the final step in active steroid hormone biosynthesis. Advances have taken place in our understanding of the unique manner that determines tissue-specific expression of P450aromatase through the utilization of alternative promoters. In recent years, evidence has been obtained for the expression of steroidogenic enzymes in the nervous system and in cardiac tissue, indicating that these tissues may be involved in the biosynthesis of steroid hormones acting in an autocrine or paracrine manner. This review presents a detailed description of the enzymes involved in the biosynthesis of active steroid hormones, with emphasis on the human and mouse enzymes and their expression in gonads, adrenal glands, and placenta.
            Article 0 comments Cited 326 times – based on 0 reviews     Review now
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              A critical assessment of docking programs and scoring functions.

              Gregory Warren, C. Webster Andrews, Anna-Maria Capelli … (2006)
              Docking is a computational technique that samples conformations of small molecules in protein binding sites; scoring functions are used to assess which of these conformations best complements the protein binding site. An evaluation of 10 docking programs and 37 scoring functions was conducted against eight proteins of seven protein types for three tasks: binding mode prediction, virtual screening for lead identification, and rank-ordering by affinity for lead optimization. All of the docking programs were able to generate ligand conformations similar to crystallographically determined protein/ligand complex structures for at least one of the targets. However, scoring functions were less successful at distinguishing the crystallographic conformation from the set of docked poses. Docking programs identified active compounds from a pharmaceutically relevant pool of decoy compounds; however, no single program performed well for all of the targets. For prediction of compound affinity, none of the docking programs or scoring functions made a useful prediction of ligand binding affinity.
              Article 0 comments Cited 286 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (nlm-ta): EFSA J
                Journal ID (iso-abbrev): EFSA J
                Journal ID (doi): 10.1002/(ISSN)1831-4732
                Journal ID (publisher-id): EFS2
                Title: EFSA Journal
                Publisher: John Wiley and Sons Inc. (Hoboken )
                ISSN (Electronic): 1831-4732
                Publication date (Electronic): 07 June 2018
                Publication date Collection: June 2018
                Volume: 16
                Issue: 6 ( doiID: 10.1002/efs2.2018.16.issue-6 )
                Electronic Location Identifier: e05311
                Author notes
                [*] Correspondence: For biological products: biocides@ 123456echa.europa.eu

                For plant protection products: pesticides.peerreview@ 123456efsa.europa.eu

                Article
                Publisher ID: EFS25311
                DOI: 10.2903/j.efsa.2018.5311
                PMC ID: 7009395
                PubMed ID: 32625944
                SO-VID: 8ecd5f1b-ea82-4751-85c0-8660d8a36cd5
                Copyright © © 2018 European Chemicals Agency and © European Food Safety Authority.
                License:

                This is an open access article under the terms of the http://creativecommons.org/licenses/by-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited and no modifications or adaptations are made.

                History
                Page count
                Figures: 9, Tables: 23, Pages: 135, Words: 73543
                Categories
                Subject: Guidance
                Subject: Guidance
                Custom metadata
                source-schema-version-number 2.0
                cover-date June 2018
                details-of-publishers-convertor Converter:WILEY_ML3GV2_TO_JATSPMC version:5.7.5 mode:remove_FC converted:21.01.2020

                Keywords: biocidal product,plant protection product,endocrine disruptor,guidance,hazard identification
                Data availability:
                Keywords: biocidal product, plant protection product, endocrine disruptor, guidance, hazard identification

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