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      Effects of Cascade Apheresis in Patients with Psoriasis and Psoriatic Arthropathy

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          Eight patients with psoriasis, all with skin scales and 7 with disabling psoriatic arthritis, were subjected to cascade apheresis starting with three treatments per week for 2 weeks, followed by one treatment a week, comprising ten treatments in all. Six out of 7 patients (86%) with arthropathy and 3 out of 8 patients (38%) with scales experienced a beneficial effect. There was a large drop in the levels of circulating immune complexes (CIC) due to the treatment, and the removal of CIC was followed by reduced inflammatory activity in skin lesions and joints as evaluated by pain, morning stiffness, grip strength, plaque score, and PASI index. However, there was no correlation between the level of CIC, disease activity, or treatment response. From the present results it is concluded that CIC may play a more significant role regarding psoriatic arthropathy than in skin manifestations, and apheresis may be beneficial in patients not responding to conventional therapy.

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          The skin barrier from a lipid perspective

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            Dialysis therapy for psoriasis. Report of three cases and review of the literature

             S. HALEVY,  S Halevy (1981)

              Author and article information

              Blood Purif
              Blood Purification
              S. Karger AG
              February 1998
              12 February 1998
              : 16
              : 1
              : 37-42
              Department of Medicine, Sections of a Nephrology, b Microbiology, and c Dermatology, and d Institute of Technology SINTEF, Norwegian University of Science and Technology, Trondheim, Norway
              14311 Blood Purif 1998;16:37–42
              © 1998 S. Karger AG, Basel

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              Tables: 3, References: 25, Pages: 6
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