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      Helicobacter pylori-associated gastritis and primary B-cell gastric lymphoma.

      1 , , ,
      Lancet (London, England)
      Elsevier BV

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          Abstract

          Although lymphoid tissue is absent in normal gastric mucosa, primary lymphomas arise in the stomach and most of these recapitulate the features of mucosa-associated lymphoid tissue (MALT). Gastric lymphoid tissue is known to be acquired in response to local infection by Helicobacter pylori, and we have confirmed this in 450 patients with H pylori-associated gastritis of whom 125 showed mucosal lymphoid follicles. In 8 patients, B lymphocytes infiltrated epithelium, which is a feature characteristic of MALT. We also examined 110 cases of gastric MALT lymphoma and found H pylori infection in 101 of these (92%). We conclude that gastric MALT is acquired in H pylori infection and that this provides the necessary background in which MALT lymphoma might develop.

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          Author and article information

          Journal
          Lancet
          Lancet (London, England)
          Elsevier BV
          0140-6736
          0140-6736
          Nov 09 1991
          : 338
          : 8776
          Affiliations
          [1 ] Department of Histopathology, University College and Middlesex School of Medicine, London, UK.
          Article
          0140-6736(91)92035-Z
          10.1016/0140-6736(91)92035-z
          1682595
          8ee94d93-e0a0-49be-b2b8-218464ae053a
          History

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