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      Reduction of Nerves Containing Vasoactive Intestinal Polypeptide and Serotonin, but Not Neuropeptide Y and Catecholamine, in Cerebral Blood Vessels of the 8-Week Streptozotocin-Induced Diabetic Rat

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          The perivascular autonomic nerves of the major blood vessels on the ventral surface of the brain were studied in the streptozotocin-induced diabetic rat, an animal model for juvenile onset of diabetes. Histochemical and immunohistochemical techniques were used to determine the pattern and density of perivascular nerves containing catecholamine, 5-hydroxytryptamine (5-HT), vasoactive intestinal polypeptide (VIP) and neuropeptide Y (NPY). A significant reduction in the density and/or fluorescence intensity of 5-HT-immunoreactive nerves was observed in the circle of Willis and its main arterial branches namely: basilar, superior cerebellar, internal carotid, posterior communicating, middle cerebral and anterior cerebral arteries, while a significant reduction of VIP-immunoreactive nerves was observed in the internal carotid, middle cerebral and anterior cerebral arteries, but not in the basilar, superior cerebellar and posterior communicating arteries 8 weeks after the onset of diabetes. However, no changes were observed in the density of NPY- and catecholamine-containing nerves. The results are discussed in relation to autonomic neuropathy of the cerebral blood vessels in diabetes.

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          Author and article information

          J Vasc Res
          Journal of Vascular Research
          S. Karger AG
          23 September 2008
          : 24
          : 4
          : 169-180
          Department of Anatomy and Embryology, and Centre for Neuroscience, University College London, UK
          158693 Blood Vessels 1987;24:169–180
          © 1987 S. Karger AG, Basel

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          Page count
          Pages: 12
          Research Paper


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