ScienceOpen:
research and publishing network
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
My ScienceOpen
Sign in
Register
Dashboard
Blog
About
Search
Advanced search
My ScienceOpen
Sign in
Register
Dashboard
Search
Search
Advanced search
For Publishers
Discovery
Metadata
Peer review
Hosting
Publishing
For Researchers
Join
Publish
Review
Collect
Blog
About
15
views
0
references
Top references
cited by
14
Cite as...
0 reviews
Review
0
comments
Comment
0
recommends
+1
Recommend
0
collections
Add to
0
shares
Share
Twitter
Sina Weibo
Facebook
Email
2,626
similar
All similar
Record
: found
Abstract
: not found
Article
: not found
Longitudinal analysis of the behavioural phenotype in YAC128 (C57BL/6J) Huntington's disease transgenic mice
Author(s):
Simon Brooks
,
Gemma Higgs
,
Nari Janghra
,
Lesley Jones
,
Stephen B. Dunnett
Publication date
Created:
June 2012
Publication date
(Print):
June 2012
Journal:
Brain Research Bulletin
Publisher:
Elsevier BV
Read this article at
ScienceOpen
Publisher
PubMed
Review
Review article
Invite someone to review
Bookmark
Cite as...
There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.
Abstract
To determine the suitability of mouse models of disease for therapeutic trials, the models must be characterised to determine their similarity to the human condition, and utility for specific therapeutic approaches. The YAC128 mouse model of HD has been bred on to C57BL/6J background in order to provide a mouse model of the disease better suited to behavioural testing, than the visually impaired original line on the FVB background. In the present study, the C57BL/6J YAC128 mice were assessed on several behavioural tasks bi-monthly between 4 and 24 months of age. On the rotarod early and stable deficits were demonstrated in the YAC128 mice from 4 months of age indicating an early abnormality in motor coordination. Early and stable deficits were also found on the balance beam measures of latency to orientate towards the beam and time to traverse it. Measures of fore and hind limb footslips on the balance beam demonstrated early and progressive limb use deficits in the YAC128 mice. On a 3-stage Morris water maze protocol, the YAC128 mice took longer and travelled further to find the hidden platform in each of the 3 locations, indicative of a spatial learning deficit. The YAC128 mice were also less reactive to the primary startle stimuli and the effects of the prepulse which may suggest striatal dysfunction. As a measure of general well being, the body weights of the mice were recorded and demonstrated increased weight in the YAC128 mice until 14 months of age, when they became comparable to that of their wildtype littermates. The YAC128 mouse on the C57BL/6J background has an early, robust and severe behavioural phenotype that shares some similarity to human HD symptomatology. Copyright © 2010 Elsevier Inc. All rights reserved.
Related collections
Asian Journal of Behavioural Studies (AjBeS)
Author and article information
Journal
Title:
Brain Research Bulletin
Abbreviated Title:
Brain Research Bulletin
Publisher:
Elsevier BV
ISSN (Print):
03619230
Publication date Created:
June 2012
Publication date (Print):
June 2012
Volume
: 88
Issue
: 2-3
Pages
: 113-120
Article
DOI:
10.1016/j.brainresbull.2010.05.005
PubMed ID:
20460143
SO-VID:
8f6bec6f-fec9-43c9-962a-50a77da1bbf7
Copyright ©
© 2012
License:
https://www.elsevier.com/tdm/userlicense/1.0/
History
Data availability:
Comments
Comment on this article
Sign in to comment
scite_
Similar content
2,626
P02-230 Evaluation of hippocampal neurogenesis in YAC128 Huntington’s disease transgenic mice
Authors:
J Gil-Mohapel
,
J.M. Simpson
,
M.A. Pouladi
…
Selective striatal neuronal loss in a YAC128 mouse model of Huntington disease
Authors:
EJ Slow
,
J. Os
,
D Rogers
…
Spontaneous Axonal ER Ca2+ Waves Mediate A Shift From Action Potential-Dependent to Independent Glutamate Release in the YAC128 HD-Model
Authors:
Mackay
See all similar
Cited by
14
New Avenues for the Treatment of Huntington’s Disease
Authors:
Amy Kim
,
Kathryn Lalonde
,
Aaron Truesdell
…
Mouse Models of Huntington’s Disease
Authors:
Pamela P. Farshim
,
Gillian P. Bates
Mouse Models of Polyglutamine Diseases: Review and Data Table. Part I
Authors:
Maciej Figiel
,
Wojciech Szlachcic
,
Pawel Switonski
…
See all cited by
Version 1
- Current
Version 1