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      Exposure to high fluoride concentration in drinking water will affect spermatogenesis and steroidogenesis in male albino rats.

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          Abstract

          Sodium fluoride (NaF) administered orally to adult male rats at a dose level of 4.5 ppm and 9.0 ppm for 75 days caused significant decrease in the body weight, brain index and testicular index. A significant decrease in sperm count, sperm motility, sperm viability and sperm function (HOS positive) with increased sperm abnormalities was also observed in NaF-exposed male rats. The activity levels of testicular steroidogenic marker enzymes 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and 17beta-hydroxysteroid dehydrogenase (17beta-HSD) were significantly decreased in NaF-treated rats indicating decreased steroidogenesis and in turn spermatogenesis in rats exposed to NaF.

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          Author and article information

          Journal
          Biometals
          Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine
          0966-0844
          0966-0844
          Jun 2005
          : 18
          : 3
          Affiliations
          [1 ] Department of Biotechnology, Sri Venkateswara University, Tirupati - 517 502, India.
          Article
          10.1007/s10534-005-0336-2
          15984565
          8f6e2806-d5bc-4c14-b9d5-c5f756e2129b
          History

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