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A68 is a component of paired helical filaments of Gerstmann-Sträussler-Scheinker disease, Indiana kindred
Fabrizio Tagliavini ,
Giorgio Giaccone ,
Frances Prelli ,
Laura Verga ,
Monica Porro ,
John Q. Trojanowski ,
Martin R. Farlow ,
Blas Frangione ,
Bernardino Ghetti ,
Orso Bugiani
July 1993
July 1993
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Abstract
Gerstmann-Sträussler-Scheinker disease in the Indiana kindred is pathologically characterized
by prion protein amyloid deposits and neurofibrillary tangles (NFT) with paired helical
filaments (PHF). Using antibodies to various domains of the tau molecule, we investigated
the composition of PHF in this family by immunocytochemistry and immunoblot analysis.
The results indicate that A68 is a component of NFT in this family as it is in Alzheimer's
disease, and suggest that post-translational modifications of tau leading to formation
of A68 are not unique to Alzheimer's disease.