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      Biofilms Invade Nephrology: Effects in Hemodialysis

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          Abstract

          Bacteria attach to surfaces and aggregate in a biopolymer matrix to form biofilm. Studies on biofilm have shown its presence in many prosthetic devices used in nephrology as well as in fluid pathways of hemodialysis plants and monitors. Once present, this community of bacteria increases resistance to biocide due to slime production and, as a result, chemical products for dialysis monitor disinfection and descaling procedures do not result in an effective treatment. Ultrapure dialysate is a goal in modern hemodialysis, and ultrafiltration is used to obtain sterile and apyrogen fluids. Microbial colonisation of ultrafilters may occur if, due to inadequate disinfection protocols, membrane is exposed to persistent bacterial contamination, and biofilm is allowed to form and to grow. As more and more data link final dialysate microbial contamination to clinical effects of bioincompatibility from chronic inflammation in dialysis patients, attention has to be focused on possibilities of biofilm avoidance.

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          Most cited references 3

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          • Abstract: not found
          • Article: not found

          Bacterial Biofilms: A Common Cause of Persistent Infections

           J Costerton (1999)
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            • Abstract: not found
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            Evidence of Bacterial Biofilm in Tubing from Hydraulic Pathway ofHemodialysis System

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              • Record: found
              • Abstract: not found
              • Article: not found

              Persistence of microflora in biofilm within fluid pathways of contemporary haemodialysis monitors (Gambro AK-10)

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                Author and article information

                Journal
                BPU
                Blood Purif
                10.1159/issn.0253-5068
                Blood Purification
                S. Karger AG
                978-3-8055-7083-1
                978-3-318-00584-4
                0253-5068
                1421-9735
                2000
                2000
                03 August 2000
                : 18
                : 3
                : 224-230
                Affiliations
                Division of Nephrology, Dialysis and Transplantation, University Hospital of Modena, Italy
                Article
                14421 Blood Purif 2000;18:224–230
                10.1159/000014421
                10859425
                © 2000 S. Karger AG, Basel

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                Page count
                Figures: 6, References: 27, Pages: 7
                Product
                Self URI (application/pdf): https://www.karger.com/Article/Pdf/14421
                Categories
                Paper

                Cardiovascular Medicine, Nephrology

                Hemodialysis, Biofilm, Ultrapure dialysate

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