- Record: found
- Abstract: found
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Conformationally constrained farnesoid X receptor (FXR) agonists: heteroaryl replacements of the naphthalene.
J. Bass, B Marr, M Spearing, T. Williams, K Creech, Lihong Chen, F Navas, G. Wisely, Jonathan Todd, Justin Miller, D H Deaton, Tirzah Mills, I McFadyen, Regenia Smalley, Kevin Madauss, Griffith Parks, J Caravella
2011-02-15
Bioorganic & Medicinal Chemistry Letters
Weight Gain, metabolism, agonists, Receptors, Cytoplasmic and Nuclear, Rats, pharmacokinetics, chemistry, chemical synthesis, Quinolines, Protein Structure, Tertiary, Naphthalenes, Molecular Conformation, Mice, Ligands, Isoxazoles, Humans, Fluorescence Resonance Energy Transfer, Dogs, Diabetes Mellitus, Experimental, Crystallography, X-Ray, Blood Glucose, Binding Sites, Animals, drug effects
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Journal
10.1016/j.bmcl.2010.12.089
21256005
Weight Gain, metabolism, agonists, Receptors, Cytoplasmic and Nuclear, Rats, pharmacokinetics, chemistry, chemical synthesis, Quinolines, Protein Structure, Tertiary, Naphthalenes, Molecular Conformation, Mice, Ligands, Isoxazoles, Humans, Fluorescence Resonance Energy Transfer, Dogs, Diabetes Mellitus, Experimental, Crystallography, X-Ray, Blood Glucose, Binding Sites, Animals, drug effects