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      Dosimetry of small photon fields in the presence of bone heterogeneity using MAGIC polymer gel, Gafchromic film, and Monte Carlo simulation

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          Abstract

          Background

          The presence of heterogeneity within the radiation field increases the challenges of small field dosimetry. In this study, the performance of MAGIC polymer gel was evaluated in the dosimetry of small fields beyond bone heterogeneity.

          Materials and methods

          Circular field sizes of 5, 10, 20 and 30 mm were used and Polytetrafluoroethylene with density of 2.2 g/cm 3 was used as the bone equivalent material. The PDD curves, beam profiles, and penumbra widths were measured using MAGIC polymer gel, EBT2 film, and Monte Carlo simulation.

          Results

          The maximum differences between MAGIC and EBT2 are 6.1, 4.7, 2.4, and 2.2 for PDD curves at 5, 10, 20, and 30 mm circular fields, respectively. The dose differences and distance to agreement between MAGIC and MC were within 1.89%/0.46 mm, 1.66%/0.43 mm, 1.28%/0.77 mm, and 1.31%/0.81 mm for beam profile values behind bone heterogeneity at 5, 10, 20, and 30 mm field sizes, respectively.

          Conclusion

          The results presented that the MAGIC polymer gel dosimeter is a proper instrument for dosimetry beyond high density heterogeneity.

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          Most cited references28

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          A new formalism for reference dosimetry of small and nonstandard fields.

          The use of small fields in radiotherapy techniques has increased substantially, in particular in stereotactic treatments and large uniform or nonuniform fields that are composed of small fields such as for intensity modulated radiation therapy (IMRT). This has been facilitated by the increased availability of standard and add-on multileaf collimators and a variety of new treatment units. For these fields, dosimetric errors have become considerably larger than in conventional beams mostly due to two reasons; (i) the reference conditions recommended by conventional Codes of Practice (CoPs) cannot be established in some machines and (ii) the measurement of absorbed dose to water in composite fields is not standardized. In order to develop standardized recommendations for dosimetry procedures and detectors, an international working group on reference dosimetry of small and nonstandard fields has been established by the International Atomic Energy Agency (IAEA) in cooperation with the American Association of Physicists in Medicine (AAPM) Therapy Physics Committee. This paper outlines a new formalism for the dosimetry of small and composite fields with the intention to extend recommendations given in conventional CoPs for clinical reference dosimetry based on absorbed dose to water. This formalism introduces the concept of two new intermediate calibration fields: (i) a static machine-specific reference field for those modalities that cannot establish conventional reference conditions and (ii) a plan-class specific reference field closer to the patient-specific clinical fields thereby facilitating standardization of composite field dosimetry. Prior to progressing with developing a CoP or other form of recommendation, the members of this IAEA working group welcome comments from the international medical physics community on the formalism presented here.
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            Dosimetry of small static fields used in external photon beam radiotherapy: Summary of TRS-483, the IAEA-AAPM international Code of Practice for reference and relative dose determination.

            A joint IAEA/AAPM international working group has developed a Code of Practice (CoP) for the dosimetry of small static fields used in external megavoltage photon beam radiotherapy, published by the IAEA as TRS-483. This summary paper introduces and outlines the main aspects of the CoP.
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              Polymer gels for magnetic resonance imaging of radiation dose distributions at normal room atmosphere.

              Polymer gels whose NMR and optical properties change when irradiated offer unique advantages for measuring radiation dose distributions. To date, all acrylic polymer gel dosimeters must be manufactured, stored and irradiated in hypoxic conditions which severely limits their use and stability. A new formulation of acrylic dosimeter gel has been developed that responds well in normal atmosphere and which we have named MAGIC (Methacrylic and Ascorbic acid in Gelatin Initiated by Copper). To produce dosimeter gels, an aqueous solution of gelatin, open to the atmosphere, is mixed with methacrylic acid, copper(II) ions, ascorbic acid and hydroquinone. It is believed that the copper(II) and ascorbic acid form a complex with oxygen which (with radiolysis of water) serves as a free radical source for the initiation of the polymerization of methacrylic acid. At room air the water proton spin relaxation rate R2 in MAGIC gels is proportional to absorbed dose though the precise relationship depends on the composition of the gel and the initiating complex. For example, in the range 0-30 Gy the slope of the response of R2 versus dose at 20 MHz was 0.300, 0.519 and 0.681 s(-1) Gy(-1), respectively, when the concentration of MAA was 3, 6 and 9%. The slopes increased to 0.310, 0.567 and 0.868 s(-1) Gy(-1) at 85 MHz. An important determinant of the sensitivity to detect small dose changes is shown to be the slope-to-intercept ratio of the dose-response curve. These varied from 0.08 to 0.17, comparable to hypoxic gels described earlier. MAGIC gels can be manufactured and used much more easily than the previous formulations and can be imaged by magnetic resonance imaging or optical scanning, and thus they will likely be of considerable interest to radiation physicists.
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                Author and article information

                Journal
                Rep Pract Oncol Radiother
                Rep Pract Oncol Radiother
                Reports of Practical Oncology and Radiotherapy
                Via Medica
                1507-1367
                2083-4640
                2022
                19 May 2022
                : 27
                : 2
                : 226-234
                Affiliations
                [1 ]Department of Medical Physics, Faculty of Paramedical Sciences, Ilam University of Medical Sciences, Ilam, Iran
                [2 ]Department of Medical Physics and Biomedical Engineering, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
                [3 ]Cancer Institute, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
                [4 ]Department of Medical Physics, School of Medicine, Semnan University of Medical Sciences, Semnan, Iran
                Author notes
                Address for correspondence: Ghazale Geraily, Medical Physics Department, Tehran University of Medical Science, Tehran, Iran, Iran Gamma Knife Center, Tehran, Iran, tel: +989124308726; e-mail: gh-geraily@ 123456sina.tums.ac.ir
                Article
                rpor-27-2-226
                10.5603/RPOR.a2022.0031
                9591029
                36299382
                8fa5c92a-d347-410d-ab1b-e15703c0e27a
                © 2022 Greater Poland Cancer Centre

                This article is available in open access under Creative Common Attribution-Non-Commercial-No Derivatives 4.0 International (CC BY-NC-ND 4.0) license, allowing to download articles and share them with others as long as they credit the authors and the publisher, but without permission to change them in any way or use them commercially

                History
                : 01 December 2021
                : 08 February 2022
                Categories
                Research Paper

                small field,bone heterogeneity,magic polymer gel,monte carlo simulation

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