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      mTOR Signaling in Growth Control and Disease

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      Cell
      Elsevier BV

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          Abstract

          The mechanistic target of rapamycin (mTOR) signaling pathway senses and integrates a variety of environmental cues to regulate organismal growth and homeostasis. The pathway regulates many major cellular processes and is implicated in an increasing number of pathological conditions, including cancer, obesity, type 2 diabetes, and neurodegeneration. Here, we review recent advances in our understanding of the mTOR pathway and its role in health, disease, and aging. We further discuss pharmacological approaches to treat human pathologies linked to mTOR deregulation. Copyright © 2012 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          Cell
          Cell
          Elsevier BV
          00928674
          April 2012
          April 2012
          : 149
          : 2
          : 274-293
          Article
          10.1016/j.cell.2012.03.017
          3331679
          22500797
          8fadd2cc-22ad-4c64-bce6-0d990a8bb00b
          © 2012

          https://www.elsevier.com/tdm/userlicense/1.0/

          https://www.elsevier.com/open-access/userlicense/1.0/

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