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      Radiochemistry, PET Imaging, and the Internet of Chemical Things

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          Abstract

          The Internet of Chemical Things (IoCT), a growing network of computers, mobile devices, online resources, software suites, laboratory equipment, synthesis apparatus, analytical devices, and a host of other machines, all interconnected to users, manufacturers, and others through the infrastructure of the Internet, is changing how we do chemistry. While in its infancy across many chemistry laboratories and departments, it became apparent when considering our own work synthesizing radiopharmaceuticals for positron emission tomography (PET) that a more mature incarnation of the IoCT already exists. How does the IoCT impact our lives today, and what does it hold for the smart (radio)chemical laboratories of the future?

          Abstract

          The Internet of Chemical Things, a network of computers and lab equipment connected via the Internet, is changing how we do chemistry today, but what does it hold for the smart laboratories of the future?

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          Most cited references27

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          The Internet of Things—A survey of topics and trends

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            Computer-Assisted Synthetic Planning: The End of the Beginning

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              On-demand continuous-flow production of pharmaceuticals in a compact, reconfigurable system.

              Pharmaceutical manufacturing typically uses batch processing at multiple locations. Disadvantages of this approach include long production times and the potential for supply chain disruptions. As a preliminary demonstration of an alternative approach, we report here the continuous-flow synthesis and formulation of active pharmaceutical ingredients in a compact, reconfigurable manufacturing platform. Continuous end-to-end synthesis in the refrigerator-sized [1.0 meter (width) × 0.7 meter (length) × 1.8 meter (height)] system produces sufficient quantities per day to supply hundreds to thousands of oral or topical liquid doses of diphenhydramine hydrochloride, lidocaine hydrochloride, diazepam, and fluoxetine hydrochloride that meet U.S. Pharmacopeia standards. Underlying this flexible plug-and-play approach are substantial enabling advances in continuous-flow synthesis, complex multistep sequence telescoping, reaction engineering equipment, and real-time formulation.
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                Author and article information

                Journal
                ACS Cent Sci
                ACS Cent Sci
                oc
                acscii
                ACS Central Science
                American Chemical Society
                2374-7943
                2374-7951
                16 August 2016
                24 August 2016
                : 2
                : 8
                : 497-505
                Affiliations
                [1] Department of Radiology and The Interdepartmental Program in Medicinal Chemistry, University of Michigan , Ann Arbor, Michigan 48109, United States
                Author notes
                Article
                10.1021/acscentsci.6b00178
                4999973
                27610410
                8fbaeb42-2651-4042-af12-7d6360f78fd2
                Copyright © 2016 American Chemical Society

                This is an open access article published under an ACS AuthorChoice License, which permits copying and redistribution of the article or any adaptations for non-commercial purposes.

                History
                : 22 June 2016
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                oc6b00178
                oc-2016-00178t

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