33
views
0
recommends
+1 Recommend
1 collections
    0
    shares
      • Record: found
      • Abstract: found
      • Article: found
      Is Open Access

      Níveis de atividade física e alterações metabólicas em pessoas vivendo com HIV/AIDS Translated title: Levels of physical activity and metabolic alterations in people living with HIV /AIDS

      research-article

      Read this article at

      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Com a introdução da highly active antiretroviral therapy (HAART) - terapia antirretroviral fortemente ativa - o curso da infecção pelo HIV sofreu profundas modificações; ocorreu aumento da sobrevida e melhora na qualidade de vida, com restauração parcial do sistema imune. Após cerca de 10 anos do uso da HAART, começaram a aparecer os efeitos da combinação tratamento/vírus. Estes incluem alterações no metabolismo dos lipídios com hipertrigliceridemia, hipercolesterolemia, resistência insulínica, hiperglicemia e redistribuição da gordura corporal que são fatores de risco para doença cardiovascular. Estudos observacionais em pessoas vivendo com HIV/AIDS mostram que o indivíduo, ao se descobrir portador da doença, acaba sentindo medo ou vergonha, reduzindo o círculo social, atividades de trabalho e lazer, e se isolando em casa ou em pequenos grupos os quais tenham em comum a identidade de portadores HIV/AIDS. O objetivo deste trabalho foi avaliar a relação entre o nível de atividade física habitual e de lazer de pessoas vivendo com HIV/AIDS e sua relação com alterações metabólicas. Os pacientes foram classificados em sedentários e ativos, utilizando o questionário de atividade física habitual proposto por Baecke e validado para pacientes HIV/AIDS. Para classificação utilizou-se as recomendações do Colégio Americano de Medicina do Esporte. O metabolismo foi avaliado por meio das dosagens de glicemia de jejum, colesterol total, HDL-colesterol, LDL-colesterol e triglicérides, utilizando-se kits comerciais. A amostra foi composta por 65 pacientes HIV que utilizavam terapia HAART há pelo menos cinco anos. Foram classificados 64,6% como sedentários e 35,4% ativos. O estudo mostra uma relação direta entre nível de atividade física e melhores níveis de HDL-colesterol em pacientes HIV/AIDS. O HDL-colesterol é uma lipoproteína de proteção cardiovascular e, embora outros parâmetros avaliados não tenham mostrado diferença, estes resultados apontam a necessidade de estudos adicionais sobre fatores de risco e atividade física para pacientes HIV/AIDS, possibilitando propostas de intervenções específicas para esses pacientes.

          Translated abstract

          The introduction of Highly Active Antiretroviral Therapy (HAART) - antiretroviral therapy highly active has deeply changed the course of HIV infection with increase in survival and improvement in quality of life as well as partial restoration of the immune system. After about ten years from the HAART use, the effects of combination treatment / virus started to come out. Among these, we can mention changes in lipid metabolism with hypertriglyceridemia, hypercholesterolemia, insulin resistance, hyperglycemia and redistribution of body fat as risk factors for cardiovascular disease. Observational studies with people living with HIV / AIDS evidence that when an individual finds out that he/she is an HIV/AIDS patient, he/she end ups feeling fear or shame, reducing hence social circle, work and leisure activities, and becomes isolated at home or in small groups which have common identity of HIV / AIDS patients. The purpose of this work was to evaluate the relationship between the level of habitual physical activity and recreation of people living with HIV / AIDS and its relation with metabolic changes. The patients were classified into active and sedentary, using the Habitual Physical Activity questionnaire proposed by Baecke and validated for HIV / AIDS patients. Classification was conducted according to the recommendations of the American College of Sports Medicine. Metabolism was assessed through plasma levels of glucose, total cholesterol, HDL-cholesterol, LDL-cholesterol and triglycerides, using commercial kits. The sample consisted of 65 HIV patients who used HAART for at least five years. 64.6% were classified as sedentary and 35.4% as active. The study shows a direct relationship between physical activity level and higher levels of HDL - cholesterol in HIV / AIDS. HDL - Cholesterol is a lipoprotein of cardiovascular protection and, although other assessed parameters have not shown difference, these results highlight the need for additional studies on risk factors and physical activity for HIV / AIDS enabling proposals for specific interventions for these patients.

          Related collections

          Most cited references37

          • Record: found
          • Abstract: found
          • Article: not found

          Metabolic syndrome among HIV-infected patients: prevalence, characteristics, and related factors.

          To assess the prevalence in HIV-infected patients of the metabolic syndrome as defined by the National Cholesterol Education Program, i.e., three or more of the following components: abdominal obesity, hypertriglyceridemia, low HDL cholesterol, high blood pressure, and high fasting glucose. In this cross-sectional study, 710 HIV-infected patients managed at the outpatient clinic of a tertiary hospital during 2003 completed the study protocol consisting of a medical examination and laboratory analysis after a 12-h overnight fast. Metabolic syndrome prevalence was 17% and increased from 5.1% among HIV-infected patients under age 30 years to 27.0% for those aged 50-59 years. Age (per 10-year increment) (odds ratio [OR] 1.41 [95% CI 1.12-1.77]), BMI (1.27 [1.19-1.36]), past and present protease inhibitor exposure (2.96 [1.03-3.55] and 4.18 [1.4-12.5], respectively) were independently associated with the metabolic syndrome on logistic regression analysis. Furthermore, only stavudine (d4T) (1.74 [1.01-2.98]) and lopinavir/ritonavir (2.46 [1.28-4.71]) were associated with the metabolic syndrome after adjustment for age and BMI. The prevalence of metabolic syndrome among these HIV-infected patients is similar to that previously reported in uninfected individuals. Of specific concern is the association of protease inhibitor exposure with the metabolic syndrome and, more specifically, with exposure to stavudine and lopinavir/ritonavir when individual antiretroviral drugs were analyzed.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Programa Nacional de DST e AIDS

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              HIV and antiretroviral therapy: lipid abnormalities and associated cardiovascular risk in HIV-infected patients.

              It has been demonstrated that patients on highly active antiretroviral therapy are at increased risk for developing metabolic abnormalities that include elevated levels of serum triglycerides and low-density lipoprotein cholesterol and reduced levels of high-density lipoprotein cholesterol. This dyslipidemia is similar to that seen in the metabolic syndrome, raising the concern that highly active antiretroviral therapy also potentially increases the risk for cardiovascular complications. This paper reviews the contribution of both HIV infection and the different components of highly active antiretroviral therapy to dyslipidemia and the role of these abnormalities toward increasing the risk of cardiovascular disease in HIV-infected patients; therapeutic strategies to manage these risks are also considered.
                Bookmark

                Author and article information

                Contributors
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Role: ND
                Journal
                rbme
                Revista Brasileira de Medicina do Esporte
                Rev Bras Med Esporte
                Sociedade Brasileira de Medicina do Exercício e do Esporte (São Paulo )
                1806-9940
                December 2012
                : 18
                : 6
                : 356-360
                Affiliations
                [1 ] Universidade Estadual de Maringá Brazil
                [2 ] Universidade Estadual de Maringá Brazil
                Article
                S1517-86922012000600001
                10.1590/S1517-86922012000600001
                8fbc85fd-4a29-408a-9e77-7306c07bede0

                http://creativecommons.org/licenses/by/4.0/

                History
                Product

                SciELO Brazil

                Self URI (journal page): http://www.scielo.br/scielo.php?script=sci_serial&pid=1517-8692&lng=en
                Categories
                PHYSIOLOGY
                SPORT SCIENCES

                Sports medicine,Anatomy & Physiology
                HIV,physical activity,metabolism,atividade física,metabolismo
                Sports medicine, Anatomy & Physiology
                HIV, physical activity, metabolism, atividade física, metabolismo

                Comments

                Comment on this article