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      Call for Papers: Green Renal Replacement Therapy: Caring for the Environment

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      About Blood Purification: 3.0 Impact Factor I 5.6 CiteScore I 0.83 Scimago Journal & Country Rank (SJR)

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      Application of Bone Marrow-Derived Stem Cells in Experimental Nephrology

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          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          Recent advancement in developmental biology has led to the discovery of immature mesenchymal stem cells in bone marrow and several established organs. The therapeutic potentials of such stem cells for treating serious diseases constitute a major rationale for every research effort, and clinical trials for replacing some damaged tissues such as cartilage are currently under way. Although the feasibility of such stem cell therapies for renal diseases remains unknown, it is worthy of pursuing possibilities. As an experimental tool, we have made chimeric rats that carry the bone marrow of transgenic rats expressing green fluorescent protein (GFP) throughout the body. All marrow lineages can be traced with bright green fluorescence regardless of their terminal phenotypes in chimeric rats. When compared with other conventional strategies for tracking bone marrow-derived cells, our system is highly sensitive and allows us to take advantage of the rat nephrology. Using this system, we have reported that bone marrow provides mesangial cells during repair process. In this manuscript, we briefly summarize our experiences.

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          Muscle Regeneration by Bone Marrow-Derived Myogenic Progenitors

          G Ferrari, Fulvio Mavilio (1998)
          Article 0 comments Cited 109 times – based on 0 reviews     Review now
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            Bone Marrow as a Potential Source of Hepatic Oval Cells

            B E Petersen (1999)
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              Oligodendrocyte precursors survive poorly and do not migrate following transplantation into the normal adult central nervous system.

              M T O'Leary, W F Blakemore (1997)
              Cell cultures enriched for oligodendrocyte precursors were prepared for male neonatal rat pups and transplanted into the spinal cord white matter of normal and x-irradiated syngeneic adult female rats. Transplanted cells were detected using a probe specific for the rat Y chromosome immediately after transplantation and 14 days later. In non-x-irradiated tissue, significantly fewer cells were seen at 14 days compared with time zero, and no cell migration was observed. In x-irradiated tissue, cells both survived and migrated into the surrounding grey and white matter. The observed behaviour of oligodendrocyte precursors in normal adult tissue is in contrast to their behaviour in myelin mutants and neonates, where migration and survival have been well documented (Warrington et al., 1993; Lachapelle et al., 1994), but mimics the behaviour of the O-2A progenitor-like cell line, CG4, following transplantation into similar environments (Franklin et al., 1996). The findings in this study have profound implications for the use of grafts of oligodendrocyte precursors as a therapy in human demyelinating diseases, because they indicate that grafts will need to be introduced directly into each clinically relevant area of demyelination.
              Article 0 comments Cited 10 times – based on 0 reviews     Review now
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                Author and article information

                Journal
                Journal ID (publisher-id): EXN
                Journal ID (nlm-ta): Nephron Exp Nephrol
                Journal ID (doi): 10.1159/issn.1660-2129
                Title: Cardiorenal Medicine
                Publisher: S. Karger AG
                ISSN (Electronic): 1660-2129
                Publication date Subscription-year: 2001
                Publication date (Print): 2001
                Publication date (Electronic): 07 November 2001
                Volume: 9
                Issue: 6
                Pages: 444-450
                Affiliations
                aOsaka University School of Medicine, Department of Internal Medicine and Therapeutics, and bOsaka University Genome Information Research Center, Suita, Osaka, Japan
                Article
                Publisher ID: 52644 Other ID: Exp Nephrol 2001;9:444–450
                DOI: 10.1159/000052644
                PubMed ID: 11702005
                SO-VID: 8fc1ce63-4301-4176-bae7-ec5cc03083ba
                Copyright © © 2001 S. Karger AG, Basel
                License:

                Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

                History
                Page count
                Figures: 3, References: 50, Pages: 7
                Categories
                Subject: Technical Seminar

                ScienceOpen disciplines: Cardiovascular Medicine,Nephrology
                Keywords: Bone marrow transplantation,Green fluorescent protein,Mesangial cell,Mesothelial cell
                Data availability:
                ScienceOpen disciplines: Cardiovascular Medicine, Nephrology
                Keywords: Bone marrow transplantation, Green fluorescent protein, Mesangial cell, Mesothelial cell

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