High-performance modified LDH for green one-pot synthesis of pyrido[2,3- d]pyrimidines

Abstract

This study introduces a new nano catalyst tailored for the eco-friendly synthesis of pyrido[2,3- d]pyrimidine via a three-component one-pot reaction involving benzaldehydes, malononitrile, and uracil. To achieve this objective, we anchored copper acetate onto the surface of layered double hydroxides modified with 1,3‑benzenedisulfonyl amide (BDSA) (LDH@PTRMS@BDSA@Cu(NO ₃) ₂), which exhibited remarkable activity and selectivity. The main benefits of this method include high product yield, swift reaction times, straightforward purification, catalyst reusability, and the employment of a mild reaction process. Furthermore, the catalyst maintained its effectiveness even after being recycled four times without notable degradation in catalytic performance.

Graphical abstract

Highlights

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  Development of a new nanocatalyst incorporating a layered double hydroxides coated with 1,3-benzenedisulfonamide.

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  The catalyst showed exceptional efficiency in the synthesis of pyrido[2,3-d]pyrimidines.

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  Products were obtained under green conditions, utilizing a one-pot three-component reaction.

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  Advantages include high product yield, short reaction duration, and low operating temperature.

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  Catalyst successfully recycled four times with negligible loss of efficiency per cycle.