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      Therapeutic implications of the gender-specific aspects of cardiovascular disease.

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      Nature reviews. Drug discovery

      Springer Nature

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          Abstract

          The manifestations of cardiovascular diseases differ between men and women, as do outcomes after therapeutic interventions. It is important that those involved in drug discovery and development, as well as disease treatment, are aware of these differences because such variations are likely to have an increasing role in therapeutic decisions in the future. Here, I review gender differences in the most frequent cardiovascular diseases and their underlying sex-dependent molecular pathophysiology, and discuss gender-specific effects of current cardiovascular drugs and the implications for novel strategies for drug development.

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          Author and article information

          Journal
          Nat Rev Drug Discov
          Nature reviews. Drug discovery
          Springer Nature
          1474-1776
          1474-1776
          May 2006
          : 5
          : 5
          Affiliations
          [1 ] Centre for Gender in Medicine and Cardiovascular Disease in Women, Charité- Universitaetsmedizin Berlin and Deutsches Herzzentrum Berlin, Augustenburger Platz 1, 13353 Berlin, Germany. vrz@dhzb.de
          Article
          nrd2032
          10.1038/nrd2032
          16672926

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