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      The sox family of transcription factors: versatile regulators of stem and progenitor cell fate.

      Cell Stem Cell
      Animals, Cell Differentiation, genetics, physiology, Humans, SOX Transcription Factors, metabolism, Stem Cells, cytology

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          Abstract

          Sox family transcription factors are well-established regulators of cell fate decisions during development. Accumulating evidence documents that they play additional roles in adult tissue homeostasis and regeneration. Remarkably, forced expression of Sox factors, in combination with other synergistic factors, reprograms differentiated cells into somatic or pluripotent stem cells. Dysregulation of Sox factors has been further implicated in diseases including cancer. Here, we review molecular and functional evidence linking Sox proteins with stem cell biology, cellular reprogramming, and disease with an emphasis on Sox2. Copyright © 2013 Elsevier Inc. All rights reserved.

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          Author and article information

          Journal
          23290134
          3608206
          10.1016/j.stem.2012.12.007

          Chemistry
          Animals,Cell Differentiation,genetics,physiology,Humans,SOX Transcription Factors,metabolism,Stem Cells,cytology

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