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      The Platin- X Series: Activation, Targeting, and Delivery

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          Abstract

          Anticancer platinum (Pt) complexes have long been pronounced as one of the biggest success stories in the history of medicinal inorganic chemistry. Yet there still remains the hunt for the “magic bullet” which can satiate the requisites of an effective chemotherapeutic drug formulation. Pt(IV) complexes are kinetically more inert that the Pt(II) congeners and offer the opportunity to append additional functional groups/ligands for prodrug activation, tumor targeting or drug delivery. The ultimate aim for functionalization is to enhance the tumor selective action and attenuate systemic toxicity of the drugs. Moreover, increase in cellular accumulation to surmount the resistance of the tumor against the drugs is also of paramount importance in drug development and discovery. In this review, we will address some of the attempts in our lab to develop Pt(IV) prodrugs that can be activated and their targeted delivery using robust nanotechnology platforms.

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          Author and article information

          Journal
          101176026
          31991
          Dalton Trans
          Dalton Trans
          Dalton transactions (Cambridge, England : 2003)
          1477-9226
          1477-9234
          6 August 2016
          16 August 2016
          16 August 2017
          : 45
          : 33
          : 12992-13004
          Affiliations
          [a ]NanoTherapeutics Research Laboratory, Department of Chemistry, University of Georgia, Athens, GA 30602
          [b ]Department of Biochemistry and Molecular Biology Miller School of Medicine, University of Miami, Miami, FL 33136
          [c ]Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136
          Author notes
          [* ]To whom correspondence should be addressed. shantadhar@ 123456med.miami.edu
          Article
          PMC4987247 PMC4987247 4987247 nihpa808665
          10.1039/c6dt01738j
          4987247
          27493131
          900b4bcc-81b7-4bb7-be77-f23623f26365
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