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      Evaluation of anti-inflammatory activity of Alstonia macrophylla Wall ex A. DC. leaf extract.

      Phytomedicine
      Acute Disease, Alstonia, Animals, Anti-Inflammatory Agents, Non-Steroidal, pharmacology, Carrageenan, administration & dosage, Chronic Disease, Dextrans, Dose-Response Relationship, Drug, Edema, chemically induced, drug therapy, Female, Granuloma, Hindlimb, drug effects, Indomethacin, Male, Phytotherapy, Plant Extracts, Plant Leaves, chemistry, Rats, Rats, Wistar, Tumor Cells, Cultured

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          Abstract

          Methanolic extract of dried leaves of Alstonia macrophylla Wall ex A. DC. and its fractions were investigated for its anti-inflammatory activity. The extract at a concentration of 200 mg kg(-1) and 400 mg kg(-1), p.o. and its fractions at 25 mg kg(-1) and 50 mg kg(-1), p.o. showed the significant dose dependent antiinflammatory activity in carrageenan and dextran-induced rats hind paw edema (acute models) as well as in cotton pellet-induced granuloma (chronic model) in rats. Anti-inflammatory activity of the tested extract and its fractions was comparable with that of the standard drug Indomethacin (10 mg kg(-1)).

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