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      Restoration of the Outer Blood-Retinal Barrier after Krypton Laser Photocoagulation

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          Abstract

          The restoration of the outer blood-retinal barrier following krypton laser injury to the rat retina was studied at small and large laser lesions using intravenously injected sodium fluorescein, horseradish peroxidase, and catalase. The regenerated choriocapillaris and new blood vessels were permeable to fluorescein and peroxidase, but not to catalase. The regenerating retinal pigment epithelium gradually reformed a continuous sheet of cells covering all small laser sites and the periphery of large lesions. Zonulae occludens between the regenerated cells restored the outer retinal barrier and prevented diffusion of peroxidase into the retina. This occurred along Bruch’s membrane and the new blood vessels that were covered by the regenerated pigment epithelial cells, but not in the center of the large lesion that was not relined by regenerated cells.

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          Author and article information

          Journal
          ORE
          Ophthalmic Res
          10.1159/issn.0030-3747
          Ophthalmic Research
          S. Karger AG
          0030-3747
          1423-0259
          1993
          1993
          11 December 2009
          : 25
          : 4
          : 201-209
          Affiliations
          aEye Research Laboratory, Department of Ophthalmology, and bDepartment of Anatomy and Structural Biology, Montefiore Medical Center/Albert Einstein College of Medicine, New York, N.Y., USA
          Article
          267314 Ophthalmic Res 1993;25:201–209
          10.1159/000267314
          8233344
          © 1993 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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