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      AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy.

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      Nature reviews. Molecular cell biology
      Springer Science and Business Media LLC

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          Abstract

          The SNF1/AMP-activated protein kinase (AMPK) family maintains the balance between ATP production and consumption in all eukaryotic cells. The kinases are heterotrimers that comprise a catalytic subunit and regulatory subunits that sense cellular energy levels. When energy status is compromised, the system activates catabolic pathways and switches off protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. Surprisingly, recent results indicate that the AMPK system is also important in functions that go beyond the regulation of energy homeostasis, such as the maintenance of cell polarity in epithelial cells.

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          Author and article information

          Journal
          Nat Rev Mol Cell Biol
          Nature reviews. Molecular cell biology
          Springer Science and Business Media LLC
          1471-0080
          1471-0072
          Oct 2007
          : 8
          : 10
          Affiliations
          [1 ] Division of Molecular Physiology, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH, Scotland, UK. d.g.hardie@dundee.ac.uk
          Article
          nrm2249
          10.1038/nrm2249
          17712357
          9022520e-9ab8-43b5-b749-41974d0972b3
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