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      Data sharing: Empty archives

      Nature

      Springer Science and Business Media LLC

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          Understanding Faculty to Improve Content Recruitment for Institutional Repositories

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            Epidemiology, data sharing, and the challenge of scientific replication.

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              DNA repair and colorectal cancer.

              The mismatch repair system plays a major role in the processing of recombination intermediates and in the repair of errors made during DNA replication or resulting from chemical damage to DNA. Human homologues of the bacterial and yeast mismatch repair genes have been recently identified, and mutations in these genes have been found to show risk for tumor development in hereditary nonpolyposis colorectal cancer syndrome (HNPCC). Colorectal tumors bearing homozygous mutations in these mismatch repair genes show a hypermutable phenotype, mainly at microsatellite regions of DNA. The temporal relationship between the loss of mismatch repair activity and the cascades of mutations in critical genes involved in the carcinogenesis of HNPCC tumors is unknown.
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                Author and article information

                Journal
                Nature
                Nature
                Springer Science and Business Media LLC
                0028-0836
                1476-4687
                September 2009
                September 9 2009
                September 2009
                : 461
                : 7261
                : 160-163
                10.1038/461160a
                19741679
                © 2009

                http://www.springer.com/tdm

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