5
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      LEAPing through the looking glass: secondary analysis of the effect of skin test size and age of introduction on peanut tolerance after early peanut introduction

      , , , , , ,
      Allergy
      Wiley-Blackwell

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Abstract

          <div class="section"> <a class="named-anchor" id="S1"> <!-- named anchor --> </a> <h5 class="section-title" id="d6270964e188">Background</h5> <p id="P1">In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high-risk 4-11 month olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high-risk factors on peanut tolerance are poorly understood. </p> </div><div class="section"> <a class="named-anchor" id="S2"> <!-- named anchor --> </a> <h5 class="section-title" id="d6270964e193">Methods</h5> <p id="P2">Secondary analysis was conducted on the publically available LEAP dataset, exploring relationships between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race. </p> </div><div class="section"> <a class="named-anchor" id="S3"> <!-- named anchor --> </a> <h5 class="section-title" id="d6270964e198">Results</h5> <p id="P3">A multiple logistic regression model predicting odds of successful oral food challenge (OFC) at 60 months noted higher odds with early introduction (OR 9.2, P&lt;0.001, 95%CI 4.2-20.3), white race (OR 2.1, p=0.04, 95%CI 1.1-3.9), and advancing age (OR 4.8, P=0.04, 95%CI 1.1-20.8). Odds of peanut tolerance were lower with increasing peanut wheal size (OR 0.58, P&lt;0.001, 95%CI 0.46-0.74), increased baseline SCORAD score (OR 0.98, p=0.04, 95%CI 0.97-1), and increased kU <sub>A</sub>/L of egg serum IgE (sIgE) (OR 0.99, p=0.04, 95%CI 0.98-1). The probability of peanut tolerance in the early introduction group was 83% vs. 43% in the avoidance group with SPT wheal of less than 4mm. The probability of a successful OFC was significantly higher with peanut introduction between 6-11 months than at 4-6 months. Increasing eczema severity had limited impact on the probability of peanut tolerance in the early introduction arm. </p> </div><div class="section"> <a class="named-anchor" id="S4"> <!-- named anchor --> </a> <h5 class="section-title" id="d6270964e206">Conclusion</h5> <p id="P4">Increasing peanut wheal size predicted peanut tolerance only in the avoidance arm. Peanut introduction between 6-11 months of age was associated with the highest rates of peanut tolerance, questioning the “urgency” of introduction before 6 months. </p> </div>

          Related collections

          Most cited references8

          • Record: found
          • Abstract: found
          • Article: not found

          Natural history of peanut allergy and predictors of resolution in the first 4 years of life: A population-based assessment.

          There are no prospectively collected data available on the natural history of peanut allergy in early childhood. Previous studies of predictors of tolerance development have been biased by failure to challenge high-risk children when IgE antibody levels are high, therefore potentially introducing bias to persistent allergy.
            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            Peanut allergy prevalence among school-age children in a US cohort not selected for any disease.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              The prevalence, natural history and time trends of peanut allergy over the first 10 years of life in two cohorts born in the same geographical location 12 years apart.

              The aim of this study was to explore the natural history of peanut allergy in childhood in two birth cohorts from the same geographical region in the South of England.
                Bookmark

                Author and article information

                Journal
                Allergy
                Allergy
                Wiley-Blackwell
                01054538
                August 2017
                August 22 2017
                : 72
                : 8
                : 1254-1260
                Article
                10.1111/all.13100
                5447487
                27896827
                902be2ab-90b5-4b10-843f-19897fff03cc
                © 2017

                http://doi.wiley.com/10.1002/tdm_license_1.1

                History

                Comments

                Comment on this article