Junji Chida: Role: Funding acquisitionRole: InvestigationRole: VisualizationRole: Writing – original
draftRole: Writing – review & editing
Hideyuki Hara: Role: Investigation
Masashi Yano: Role: Investigation
Keiji Uchiyama:
ORCID: http://orcid.org/0000-0002-5667-3509
Role: Investigation
Nandita Rani Das: Role: Investigation
Etsuhisa Takahashi: Role: Resources
Hironori Miyata: Role: Resources
Yukiko Tomioka: Role: Investigation
Toshihiro Ito: Role: Investigation
Hiroshi Kido: Role: Resources
Suehiro Sakaguchi:
ORCID: http://orcid.org/0000-0002-8824-3124
Role: ConceptualizationRole: Funding acquisitionRole: InvestigationRole: ResourcesRole:
SupervisionRole: Writing – original draftRole: Writing – review & editing
Daniel R. Perez: Role: Editor
Journal ID (nlm-ta): PLoS Pathog
Journal ID (iso-abbrev): PLoS Pathog
Journal ID (publisher-id): plos
Journal ID (pmc): plospath
Title:
PLoS Pathogens
Publisher:
Public Library of Science
(San Francisco, CA USA
)
ISSN
(Print):
1553-7366
ISSN
(Electronic):
1553-7374
Publication date
(Electronic):
3
May
2018
Publication date Collection:
May
2018
Volume: 14
Issue: 5
Electronic Location Identifier: e1007049
Affiliations
[1
]
Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima
University, Tokushima, Japan
[2
]
Division of Enzyme Chemistry, Institute for Enzyme Research, Tokushima University,
Tokushima, Japan
[3
]
Animal Research Center, School of Medicine, University of Occupational and Environmental
Health, Kitakyushu, Japan
[4
]
Avian Zoonosis Research Center, Faculty of Agriculture, Tottori University, Koyama-cho,
Tottori, Japan
University of Georgia, UNITED STATES
Author notes
The authors declare no competing financial interests.
Author information
Article
Publisher ID:
PPATHOGENS-D-17-01127
DOI: 10.1371/journal.ppat.1007049
PMC ID: 5953499
PubMed ID: 29723291
SO-VID: 906189e3-2c73-4893-8229-74d69de95a70
Copyright © © 2018 Chida et al
License:
This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided
the original author and source are credited.
Funded by: Research Committee of Molecular Pathogenesis and Therapies for Prion Disease and Slow
Virus Infection, Research on Rare and Intractable Diseases, Health and Labour Sciences
Research Commissions, The Ministry of Health, Labour and Welfare, Japan
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8824-3124
Suehiro Sakaguchi
Funded by: JSPS KAKENHI
Award ID: 26293212
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8824-3124
Suehiro Sakaguchi
Funded by: JSPS KAKENHI
Award ID: 15K15380
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8824-3124
Suehiro Sakaguchi
Funded by: Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging and
Dementia Control) from MEXT
Award ID: 15H01560, 17H05701
Award Recipient
:
ORCID: http://orcid.org/0000-0002-8824-3124
Suehiro Sakaguchi
Funded by: JSPS KAKENHI
Award ID: 16K10029
Award Recipient
:
Junji Chida
Funded by: Cooperative Research Grant of the Institute for Enzyme Research, the University of
Tokushima
Award Recipient
:
Hironori Miyata
This work was partly supported to SS by the Research Committee of Molecular Pathogenesis
and Therapies for Prion Disease and Slow Virus Infection, Research on Rare and Intractable
Diseases, Health and Labour Sciences Research Commissions, The Ministry of Health,
Labour and Welfare, Japan (
http://www.mhlw.go.jp/english/), JSPS KAKENHI Grant Number 26293212 (
https://www.jsps.go.jp/english/e-grants/) and 15K15380 and 17K19661 (
https://www.jsps.go.jp/english/e-grants/), and Grant-in-Aid for Scientific Research on Innovative Areas (Brain Protein Aging
and Dementia Control) Grant Number 15H01560, 17H05701 from MEXT (
http://www.mext.go.jp/), to JC by JSPS KAKENHI Grant Number 16K10029 (
https://www.jsps.go.jp/english/e-grants/), and to HM by a Cooperative Research Grant of the Institute for Enzyme Research,
the University of Tokushima. The funders had no role in study design, data collection
and analysis, decision to publish, or preparation of the manuscript.
Subject:
Research Article
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
RNA viruses
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Microbiology
Subject:
Medical microbiology
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Medicine and health sciences
Subject:
Pathology and laboratory medicine
Subject:
Pathogens
Subject:
Microbial pathogens
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and life sciences
Subject:
Organisms
Subject:
Viruses
Subject:
Viral pathogens
Subject:
Orthomyxoviruses
Subject:
Influenza viruses
Subject:
Influenza A virus
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cellular Types
Subject:
Animal Cells
Subject:
Epithelial Cells
Subject:
Biology and Life Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Medicine and Health Sciences
Subject:
Anatomy
Subject:
Biological Tissue
Subject:
Epithelium
Subject:
Epithelial Cells
Subject:
Biology and Life Sciences
Subject:
Cell Biology
Subject:
Cell Processes
Subject:
Cell Death
Subject:
Apoptosis
Subject:
Research and Analysis Methods
Subject:
Immunologic Techniques
Subject:
Immunoassays
Subject:
Enzyme-Linked Immunoassays
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Immune Physiology
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Medicine and Health Sciences
Subject:
Immunology
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Immune System Proteins
Subject:
Antibodies
Subject:
Biology and Life Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Medicine and Health Sciences
Subject:
Physiology
Subject:
Physiological Parameters
Subject:
Body Weight
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Enzymology
Subject:
Enzymes
Subject:
Dismutases
Subject:
Superoxide Dismutase
Subject:
Biology and Life Sciences
Subject:
Biochemistry
Subject:
Proteins
Subject:
Enzymes
Subject:
Dismutases
Subject:
Superoxide Dismutase
Subject:
Biology and Life Sciences
Subject:
Population Biology
Subject:
Population Metrics
Subject:
Death Rates