18
views
0
recommends
+1 Recommend
0 collections
    0
    shares
      • Record: found
      • Abstract: not found
      • Article: not found

      Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth

      1 , 2 , 3 , 4 , 5
      Cochrane Pregnancy and Childbirth Group
      Cochrane Database of Systematic Reviews
      Wiley

      Read this article at

      ScienceOpenPublisherPMC
      Bookmark
          There is no author summary for this article yet. Authors can add summaries to their articles on ScienceOpen to make them more accessible to a non-specialist audience.

          Related collections

          Most cited references135

          • Record: found
          • Abstract: not found
          • Article: not found

          Measuring inconsistency in meta-analyses.

            Bookmark
            • Record: found
            • Abstract: not found
            • Article: not found

            A controlled trial of antepartum glucocorticoid treatment for prevention of the respiratory distress syndrome in premature infants.

              Bookmark
              • Record: found
              • Abstract: found
              • Article: not found

              Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth.

              Respiratory distress syndrome (RDS) is a serious complication of preterm birth and the primary cause of early neonatal mortality and disability. To assess the effects on fetal and neonatal morbidity and mortality, on maternal mortality and morbidity, and on the child in later life of administering corticosteroids to the mother before anticipated preterm birth. We searched the Cochrane Pregnancy and Childbirth Group Trials Register (30 October 2005). Randomised controlled comparisons of antenatal corticosteroid administration (betamethasone, dexamethasone, or hydrocortisone) with placebo or with no treatment given to women with a singleton or multiple pregnancy, expected to deliver preterm as a result of either spontaneous preterm labour, preterm prelabour rupture of the membranes or elective preterm delivery. Two review authors assessed trial quality and extracted data independently. Twenty-one studies (3885 women and 4269 infants) are included. Treatment with antenatal corticosteroids does not increase risk to the mother of death, chorioamnionitis or puerperal sepsis. Treatment with antenatal corticosteroids is associated with an overall reduction in neonatal death (relative risk (RR) 0.69, 95% confidence interval (CI) 0.58 to 0.81, 18 studies, 3956 infants), RDS (RR 0.66, 95% CI 0.59 to 0.73, 21 studies, 4038 infants), cerebroventricular haemorrhage (RR 0.54, 95% CI 0.43 to 0.69, 13 studies, 2872 infants), necrotising enterocolitis (RR 0.46, 95% CI 0.29 to 0.74, eight studies, 1675 infants), respiratory support, intensive care admissions (RR 0.80, 95% CI 0.65 to 0.99, two studies, 277 infants) and systemic infections in the first 48 hours of life (RR 0.56, 95% CI 0.38 to 0.85, five studies, 1319 infants). Antenatal corticosteroid use is effective in women with premature rupture of membranes and pregnancy related hypertension syndromes. The evidence from this new review supports the continued use of a single course of antenatal corticosteroids to accelerate fetal lung maturation in women at risk of preterm birth. A single course of antenatal corticosteroids should be considered routine for preterm delivery with few exceptions. Further information is required concerning optimal dose to delivery interval, optimal corticosteroid to use, effects in multiple pregnancies, and to confirm the long-term effects into adulthood.
                Bookmark

                Author and article information

                Journal
                146518
                Cochrane Database of Systematic Reviews
                Wiley
                14651858
                March 21 2017
                Affiliations
                [1 ]Obstetrics Directorate; Liverpool Women's NHS Foundation Trust; Liverpool UK
                [2 ]Auckland New Zealand
                [3 ]Department of Clinical Sciences; Liverpool School of Tropical Medicine; Liverpool UK
                [4 ]Departments of Surgery and Paediatrics: Child and Youth Health; The University of Auckland; Auckland New Zealand
                [5 ]Children's Emergency Department; Starship Children's Hospital; Auckland New Zealand
                Article
                10.1002/14651858.CD004454.pub3
                6464568
                28321847
                90647d7b-d41b-4a98-b0a8-3654461d1986
                © 2017
                History

                Comments

                Comment on this article