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      Otoprotective Effects of Stephania tetrandra S. Moore Herb Isolate against Acoustic Trauma

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          Abstract

          Noise is the most common occupational and environmental hazard, and noise-induced hearing loss (NIHL) is the second most common form of sensorineural hearing deficit. Although therapeutics that target the free-radical pathway have shown promise, none of these compounds is currently approved against NIHL by the United States Food and Drug Administration. The present study has demonstrated that tetrandrine (TET), a traditional Chinese medicinal alkaloid and the main chemical isolate of the Stephania tetrandra S. Moore herb, significantly attenuated NIHL in CBA/CaJ mice. TET is known to exert antihypertensive and antiarrhythmic effects through the blocking of calcium channels. Whole-cell patch-clamp recording from adult spiral ganglion neurons showed that TET blocked the transient Ca 2+ current in a dose-dependent manner and the half-blocking concentration was 0.6 + 0.1 μM. Consistent with previous findings that modulations of calcium-based signaling pathways have both prophylactic and therapeutic effects against neural trauma, NIHL was significantly diminished by TET administration. Importantly, TET has a long-lasting protective effect after noise exposure (48 weeks) in comparison to 2 weeks after noise exposure. The otoprotective effects of TET were achieved mainly by preventing outer hair cell damage and synapse loss between inner hair cells and spiral ganglion neurons. Thus, our data indicate that TET has great potential in the prevention and treatment of NIHL.

          Electronic supplementary material

          The online version of this article (10.1007/s10162-018-00690-3) contains supplementary material, which is available to authorized users.

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          Author and article information

          Contributors
          yueryanzi2003@163.com
          yahu1985@126.com
          jbao@neomed.edu
          jmulvanygateway@gmail.com
          bielefeld.6@osu.edu
          harrison.420@osu.edu
          neton.2@buckeyemail.osu.edu
          thirumalapd@upmc.edu
          ychen2@neomed.edu
          dlei@neomed.edu
          aqiu@gatewaybiotechnology.com
          Qing.Zheng@UHhospitals.org
          jihao5114@sina.com
          cpf_80@yahoo.com.mx
          enyamoah@gmail.com
          psalehi@creighton.edu
          Journal
          J Assoc Res Otolaryngol
          J. Assoc. Res. Otolaryngol
          JARO: Journal of the Association for Research in Otolaryngology
          Springer US (New York )
          1525-3961
          1438-7573
          5 September 2018
          December 2018
          : 19
          : 6
          : 653-668
          Affiliations
          [1 ]The First People’s Hospital of Zhangjiagang, 68 W Jiyang Road, Zhangjiagang City, 215600 Jiangsu China
          [2 ] ISNI 0000 0004 0459 7529, GRID grid.261103.7, Translational Research Center, , Northeast Ohio Medical University, ; Rootstown, OH 44272 USA
          [3 ] ISNI 0000 0001 2164 3847, GRID grid.67105.35, Department of Otolaryngology-Head and Neck Surgery, , Case Western Reserve University School of Medicine, ; Cleveland, OH 44106 USA
          [4 ] ISNI 0000 0004 1803 0208, GRID grid.452708.c, Department of Otolaryngology Head and Neck Surgery, , The Second Xiangya Hospital of Central South University, ; Changsha, 440011 Hunan China
          [5 ]Department of Research and Development, Gateway Biotechnology Inc., Rootstown, OH 44272 USA
          [6 ] ISNI 0000 0001 2285 7943, GRID grid.261331.4, Department of Speech and Hearing Science, , Ohio State University, ; Columbus, OH 43210 USA
          [7 ] ISNI 0000 0001 0650 7433, GRID grid.412689.0, The University of Pittsburgh Medical Center, ; Suite B-400, 200 Lothrop Street, Pittsburgh, PA 15213 USA
          [8 ] ISNI 0000 0004 1936 914X, GRID grid.266818.3, Department of Physiology and Cell Biology, , University of Nevada Reno, ; 1664 North Virginia St, Reno, NV 89557 USA
          Article
          PMC6249158 PMC6249158 6249158 690
          10.1007/s10162-018-00690-3
          6249158
          30187298
          906bcd8a-779b-4af1-b823-5e81d7b7a10a
          © Association for Research in Otolaryngology 2018
          History
          : 6 March 2017
          : 8 July 2018
          Funding
          Funded by: FundRef http://dx.doi.org/10.13039/100000002, National Institutes of Health;
          Award ID: AT008922
          Categories
          Research Article
          Custom metadata
          © Association for Research in Otolaryngology 2018

          synapse,calcium channel,noise-induced hearing loss,Tetrandrine,hair cells, Stephania tetrandra ,spiral ganglion neurons

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