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      Growth Factors and Pericellular Components as a Local Signalling Relay in the Action of Systemic Hormones

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          Abstract

          Recent years have shown that peptidic signals, originally identified as growth factors, may represent a local signalling system involved in the regulation of cell function under the dependence of systemic hormones. As an example, (i) adrenocortical cells are highly sensitive to transforming growth factor-β (TGFβ) which is a powerful inhibitor of their differentiated functions; (ii) adrenocortical cells produce and secrete TGFβ, which is present in the adrenal cortex in situ; (iii) adrenocorticotropin (ACTH), which is the best known positive effector of adrenocortical functions induces an up-regulation of TGFβ receptors in adrenocortical cells. Altogether, these observations suggest that TGFβ may be a local signalling system acting in balance with the systemic hormone ACTH to eventually tune the ability of adrenocortical cells to produce corticosteroids.

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          Author and article information

          Journal
          HRE
          Horm Res Paediatr
          10.1159/issn.1663-2818
          Hormone Research in Paediatrics
          S. Karger AG
          978-3-8055-6037-5
          978-3-318-00054-2
          1663-2818
          1663-2826
          1994
          1994
          05 December 2008
          : 42
          : 1-2
          : 35-38
          Affiliations
          CEA, Biochimie des Régulations Cellulaires Endocrines, INSERM Unit 244 DBMS, CEN. G, Grenoble, France
          Article
          184142 Horm Res 1994;42:35–38
          10.1159/000184142
          7959632
          © 1994 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 4
          Categories
          Growth Factors in Endocrinology: Recent Advances, Therapeutic Prospects

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