Cysteinyl leukotriene 1 receptors as novel mechanosensors mediating myogenic tone together with angiotensin II type 1 receptors-brief report.

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Abstract

Myogenic vasoconstriction is mediated by vascular smooth muscle cells of resistance arteries sensing mechanical stretch. Angiotensin II AT1 receptors and in particular AT1BRs in murine vascular smooth muscle cells have been characterized as mechanosensors that cannot fully account for myogenic vasoconstriction observed. Therefore, we aimed at uncovering novel vascular mechanosensors by expression profiling and functional characterization of candidate proteins.

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Journal

Journal ID (iso-abbrev): Arterioscler. Thromb. Vasc. Biol.

Title: Arteriosclerosis, thrombosis, and vascular biology

Publisher: Ovid Technologies (Wolters Kluwer Health)

ISSN (Electronic): 1524-4636

ISSN (Print): 1079-5642

Publication date (Electronic): Jan 2015

Volume: 35

Issue: 1

Affiliations

[1 ] From the Walther Straub Institute of Pharmacology and Toxicology (U.S., S.B., T.G., M.MyS.), Ludwig Maximilians University of Munich, Munich, Germany; and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (T.G., M.MyS.), Munich, Germany.

[2 ] From the Walther Straub Institute of Pharmacology and Toxicology (U.S., S.B., T.G., M.MyS.), Ludwig Maximilians University of Munich, Munich, Germany; and DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance (T.G., M.MyS.), Munich, Germany. mederos@lrz.uni-muenchen.de thomas.gudermann@lrz.uni-muenchen.de.

Article

Publisher Item ID: ATVBAHA.114.304844

DOI: 10.1161/ATVBAHA.114.304844

PubMed ID: 25395620

SO-VID: 906fd988-fb55-4acd-8357-476868724f99

History

Keywords: G-protein–coupled receptors

Data availability:

Keywords: G-protein–coupled receptors

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