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Elevation of carbohydrate antigen 125 in chronic heart failure may be caused by mechanical extension of mesothelial cells from serous cavity effusion.
Feifei Huang
1 ,
Kun Zhang ,
Jie Chen ,
Qingqing Cai ,
Xun Liu ,
Tong Wang ,
Zhiyue Lv ,
Jingfeng Wang ,
Hui Huang
Nov 2013
A/G,
AAO,
ALB,
AOR,
AUC,
CA125,
CHF,
Carbohydrate antigen 125,
Chronic heart failure,
DBP,
GLB,
IVSd,
LA,
LVDd,
LVEF,
LVPWd,
M/F,
MeT-5A,
N-terminal pro-brain natriuretic peptide,
NT-proBNP,
NYHA,
New York Heart Association classes,
Oxidative stress,
ROC,
RT-PCR,
RVDd,
SBP,
SCE,
SOD,
Serous cavity effusion,
Systemic inflammation,
TP,
albumin,
albumin/globulin ratio,
aortic root,
areas under the curve,
ascending aorta,
carbohydrate antigen 125,
chronic heart failure,
diastolic blood pressure,
globulin,
high-sensitivity C-reactive protein,
hsCRP,
human mesothelial cell line,
interventricular septum depth,
left atrium,
left ventricular diastolic dimension,
left ventricular ejection fraction,
left ventricular posterior wall depth,
male/female,
receiver operator characteristic,
reverse transcription polymerase chain reaction,
right ventricular diastolic dimension,
serous cavity effusion,
superoxide dismutase,
systolic blood pressure,
total protein
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Abstract
The practical application of elevated carbohydrate antigen 125 (CA125) to predict clinical outcome in chronic heart failure (CHF) is under debate. The mechanism for this CA125 elevation remains unknown. We hypothesize that mechanical stress on mesothelial cells initiates CA125 synthesis.
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Author and article information
ROC,RT-PCR,RVDd,areas under the curve,Carbohydrate antigen 125,SBP,N-terminal pro-brain natriuretic peptide,New York Heart Association classes,SCE,left ventricular diastolic dimension,CHF,GLB,DBP,ascending aorta,LVEF,carbohydrate antigen 125,NYHA,diastolic blood pressure,CA125,albumin/globulin ratio,SOD,Serous cavity effusion,MeT-5A,aortic root,Systemic inflammation,albumin,TP,A/G,human mesothelial cell line,left atrium,hsCRP,left ventricular ejection fraction,left ventricular posterior wall depth,high-sensitivity C-reactive protein,receiver operator characteristic,NT-proBNP,M/F,globulin,AOR,chronic heart failure,AAO,male/female,superoxide dismutase,Chronic heart failure,interventricular septum depth,right ventricular diastolic dimension,total protein,systolic blood pressure,LVPWd,reverse transcription polymerase chain reaction,serous cavity effusion,IVSd,LA,Oxidative stress,AUC,ALB,LVDd
ROC, RT-PCR, RVDd, areas under the curve, Carbohydrate antigen 125, SBP, N-terminal pro-brain natriuretic peptide, New York Heart Association classes, SCE, left ventricular diastolic dimension, CHF, GLB, DBP, ascending aorta, LVEF, carbohydrate antigen 125, NYHA, diastolic blood pressure, CA125, albumin/globulin ratio, SOD, Serous cavity effusion, MeT-5A, aortic root, Systemic inflammation, albumin, TP, A/G, human mesothelial cell line, left atrium, hsCRP, left ventricular ejection fraction, left ventricular posterior wall depth, high-sensitivity C-reactive protein, receiver operator characteristic, NT-proBNP, M/F, globulin, AOR, chronic heart failure, AAO, male/female, superoxide dismutase, Chronic heart failure, interventricular septum depth, right ventricular diastolic dimension, total protein, systolic blood pressure, LVPWd, reverse transcription polymerase chain reaction, serous cavity effusion, IVSd, LA, Oxidative stress, AUC, ALB, LVDd