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Clostridium difficile toxin was detected in the feces of 10.5% of normal newborn infants
and 55% of neonates in the intensive care unit. None of the normal infants and less
than one-third of those in the NICU had any signs of enteric illness. Vaginal delivery
and breast-feeding were associated with increased rates of toxin carriage. Although
toxin was not detected during antibiotic therapy, it could be found in 85% of infants
two weeks or more, and for at least an additional two months, following exposure to