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      Changes in Small Vessel Blood Content of the Rat Heart Induced by Hypercapnic, Hyperoxic or Asphyxic Conditions

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          Abstract

          The small vessel blood content (SVBC) of the ventricular walls of the heart of anesthetized closed chest rats was determined using <sup>59</sup>FeCl<sub>3</sub> to label the plasma siderophilin. SVBC was measured breathing air, 100% O<sub>2’</sub>, 5% CO<sub>2’</sub> in 21% O<sub>2’</sub> and during asphyxia. The average SVBC could be ranked: air < 100% O<sub>2’</sub> < 5% CO<sub>2</sub> < asphyxia. Only the ‘100% O<sub>2</sub>’ values were not significantly above the ‘air’ values. Under control conditions, SVBC of the rat heart averaged 6.77 ± (SE) 0.23 ml blood/100 g tissue. Inhalation of 5% CO<sub>2</sub> increased this to 8.68 ± 0.34, while asphyxia produced a maximal response to 14.40 ± 0.77. Comparison of SVBC were made between various regions of the ventricular walls. The only significant difference was that the right side of the septum had a lower SVBC than the left ventricular sub-epicardium under all conditions except CO<sub>2</sub>. These differences in SVBC are related to the number of open capillaries in the myocardium. Thus inhalation of CO<sub>2</sub> decreases intercapillary distance while 100% O<sub>2</sub> has no effect.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1978
          1978
          31 October 2008
          : 63
          : 4
          : 199-207
          Affiliations
          Department of Physiology, College of Medicine and Dentistry of New Jersey -Rutgers Medical School, Piscataway, N.J.
          Article
          169898 Cardiology 1978;63:199–207
          10.1159/000169898
          26467
          © 1978 S. Karger AG, Basel

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          Page count
          Pages: 9
          Categories
          Original Paper

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