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Dihydroceramide-desaturase-1-mediated caspase 9 activation through ceramide plays a pivotal role in palmitic acid-induced HepG2 cell apoptosis.
Qun Zhu
1
,
2
,
3 ,
Jianjun Yang
1 ,
Rongping Zhu
1 ,
Xin Jiang
4 ,
Wanlian Li
4 ,
Songqing He
5
,
6 ,
Junfei Jin
7
,
8
,
9
September 2016
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Abstract
In this study, results showed that the inhibition of PA-induced HepG2 cell growth takes place in a time- and concentration-dependent manner, that activation of caspase 9 is necessary for PA-induced HepG2 cell apoptosis, that dihydroceramide desaturase 1 (DES1) plays a key role in PA-mediated caspase 9 and caspase 3 activation, and that palmitoleic acid (POA), an omega-7 monounsaturated fatty acid, reverses PA-induced apoptosis through DES1 → Ceramide → Caspase 9 → Caspase 3 signaling.