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      The Effect of Glutamine Supplementation on Oxidative Stress and Matrix Metalloproteinase 2 and 9 After Exhaustive Exercise

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          Abstract

          Background

          Glutamine is the most abundant amino acid in plasma and skeletal muscles and an important fuel for immune system cells. It has beneficial anti-inflammatory and antioxidant properties which may be considered as a potentially useful supplement for athletes. The present study was conducted to investigate the effect of glutamine supplementation on oxidative stress and matrix metalloproteinase 2 and 9 after exhaustive exercise in young healthy males.

          Materials and methods

          In this study, 30 healthy males (supplement =15 and control=15) were randomly assigned into two groups. The supplement group received 0.3 g/kg BW of glutamine along with 25 gr of sugar dissolved in 250 cc water per day. The control group received 25 gr of sugar in 250 cc water per day. Fasting blood samples were taken at baseline and at the end of 14 days of intervention. The participants underwent exercise until experiencing full-body exhaustive fatigue for 16 ± 2.84 mins, and then fasting blood samples were taken. Serum levels of TAC, MDA, MMP2, MMP9, glutathione, and hs-CRP were measured.

          Results

          Serum levels of MDA and hs-CRP significantly decreased in the supplement group (p< 0.05). The serum level of TAC significantly increased in the supplement group (p< 0.05). Glutathione serum levels significantly increased after exhaustive exercise (p< 0.05). Serum levels of MMP2 and MMP9 remained unchanged.

          Conclusion

          Results of this study showed that, some biochemical factors are time-dependent and can increase or decrease over time, as well as, serum levels of hs-CRP and MDA decreased with glutamine supplementation along with the increase in the TAC serum levels, but this supplementation had no effect on serum levels of MMP2 and MMP9 in exhaustive exercise.

          Most cited references51

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          Cold water immersion and recovery from strenuous exercise: a meta-analysis.

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            Comparative analysis of physiologic responses to three different maximal graded exercise test protocols in healthy women.

            The purpose of this study was to compare the three most commonly used maximal graded exercise test (GXT) protocols in healthy women. Submaximal and maximal metabolic and hemodynamic responses were determined from two treadmill protocols, Bruce and Balke, and a bicycle protocol, in 49 women. Maximum oxygen uptake (VO2 max) was significantly different among protocols (Bruce=40.3, Balke=38.4, and Bike=36.6 ml/kg . min -1). Maximum heart rate (HR max) was significantly lower during Bike (178 beats/min) than during Bruce (182) and Balke (183) protocols. No differences in rate of increase in HR or systolic blood pressure (BP) per increase in multiples of the rest metabolic (METs) were found between Bruce and Balke protocols. The rate of recovery of HR and systolic BP was not different among tests. Comparisons of active and sedentary groups showed differences in VO2 max and submaximal HR and recovery HR at common minutes; however, the rate of increase in HR and systolic BP during exercise and the rate of decrease during recovery were not significantly different. Prediction of VO2 max with Bruce and Balke protocols from treadmill time was r=0.91 (SEE +/- 2.7 ml/kg . min -1) and r=0.94 (SEE 2.2 ml/kg . min -1), respectively. These data suggest a difference between men and women in increased HR and systolic BP per METs increase in exertion.
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              Plasma total antioxidant capacity, lipid peroxidation, and erythrocyte antioxidant enzyme activities in patients with rheumatoid arthritis and osteoarthritis.

              The metabolism of cells in inflammatory and noninflammatory arthritic joint diseases is subject to complex environmental controls. The aim of the present study was to investigate the total antioxidant capacity (TAC), levels of lipid peroxidation (LPO), and antioxidant enzyme activities in patients with rheumatoid arthritis (RA) and osteoarthritis (OA). Plasma levels of TAC, malondialdehyde (MDA), the activities of some erythrocyte antioxidant enzymes, as well as erythrocyte sedimentation rates (ESR) were estimated in patients with RA and OA and compared with controls. The plasma TAC levels were significantly lower in the RA group than the OA and control group (P 0.05). ESR were significantly higher in RA patients than in healthy subjects and patients with OA (P < 0.01). Moreover, there were significant negative correlations between TAC vs. MDA, ESR vs. TAC, and a positive correlation between ESR vs. MDA in the RA group (r = -0.398, P < 0.05; r = -0.422, P < 0.05; r = 0.530, P < 0.05, respectively). Our results demonstrated that levels of LPO are increased in patients with RA compared to patients with OA. In addition, plasma TAC levels are decreased in RA due to its inflammatory character. We conclude that detecting plasma TAC levels with this novel method may be used as a routine and rapid test to verify the levels of oxidative stress in RA. Furthermore, correlating TAC and LPO levels with acute phase reactants such as ESR may give some clues about disease activity in RA.
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                Author and article information

                Journal
                Drug Des Devel Ther
                Drug Des Devel Ther
                DDDT
                dddt
                Drug Design, Development and Therapy
                Dove
                1177-8881
                11 December 2019
                2019
                : 13
                : 4215-4223
                Affiliations
                [1 ]Ardabil University of Medical Sciences, School of Medicine, Department of Clinical Biochemistry , Ardabil, Iran
                [2 ]University of Mohaghegh Ardabili, Department of Exercise and Physiology , Ardabil, Iran
                Author notes
                Correspondence: Reza Alipanah-Moghadam Tel +98 9141571167 Email alipanahreza9@gmail.com
                Author information
                http://orcid.org/0000-0002-8428-2409
                http://orcid.org/0000-0002-7194-2607
                http://orcid.org/0000-0001-7231-7857
                Article
                218606
                10.2147/DDDT.S218606
                6912001
                31849453
                90a86efc-ac21-432d-a245-b0e269d9d928
                © 2019 Nemati et al.

                This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License ( http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms ( https://www.dovepress.com/terms.php).

                History
                : 06 June 2019
                : 04 December 2019
                Page count
                Tables: 4, References: 55, Pages: 9
                Categories
                Original Research

                Pharmacology & Pharmaceutical medicine
                glutamine,oxidative stress,exhaustive exercise,mmp2&9
                Pharmacology & Pharmaceutical medicine
                glutamine, oxidative stress, exhaustive exercise, mmp2&9

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