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      A phase I study of OncoVEXGM-CSF, a second-generation oncolytic herpes simplex virus expressing granulocyte macrophage colony-stimulating factor.

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          Abstract

          To conduct a phase I clinical trial with a second-generation oncolytic herpes simplex virus (HSV) expressing granulocyte macrophage colony-stimulating factor (Onco VEXGM-CSF) to determine the safety profile of the virus, look for evidence of biological activity, and identify a dosing schedule for later studies.

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          Author and article information

          Journal
          Clin Cancer Res
          Clinical cancer research : an official journal of the American Association for Cancer Research
          American Association for Cancer Research (AACR)
          1078-0432
          1078-0432
          Nov 15 2006
          : 12
          : 22
          Affiliations
          [1 ] Department of Cancer Medicine, Imperial College School of Medicine, Royal Marsden Hospital, London, UK.
          Article
          12/22/6737
          10.1158/1078-0432.CCR-06-0759
          17121894
          90afcfec-79ef-4295-b73a-00b68e221bd4
          History

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