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      Synergistic Actions of Nitrite-β-Adrenergic Blocking Agents in the Therapy of Angina Pectoris

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          Abstract

          Nitrites and β-adrenergic blocking agents reduce myocardial oxygen consumption by different mechanisms and may therefore act additively, and perhaps synergistically in angina s pectoris. Furthermore, the beneficial effects of one drug may counteract the undesirable effects of the other, thus enhancing the results of therapy while decreasing its secondary effects. Controlled-release oral nitroglycerin has now been shown to induce cardiovascular responses which are similar to those of sublingual nitroglycerin, but last significantly longer. This suggests that combining β-blockers with controlled-release oral nitroglycerin may be a useful approach to anti-anginal prophylaxis.

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          Author and article information

          Journal
          CRD
          Cardiology
          10.1159/issn.0008-6312
          Cardiology
          S. Karger AG
          0008-6312
          1421-9751
          1973
          1973
          29 October 2008
          : 58
          : 6
          : 313-325
          Affiliations
          Division of Cardiology, Department of Medicine, Albert Einstein College of Medicine, New York, N.Y., and Yale University School of Medicine, New Haven, Conn.
          Article
          169649 Cardiology 1973;58:313–325
          10.1159/000169649
          4153989
          © 1973 S. Karger AG, Basel

          Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher. Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug. Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.

          Page count
          Pages: 13
          Categories
          Editorial Review

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