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      Mitochondrial retrograde signaling.

      1 ,
      Annual review of genetics
      Annual Reviews

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          Abstract

          Mitochondrial retrograde signaling is a pathway of communication from mitochondria to the nucleus under normal and pathophysiological conditions. The best understood of such pathways is retrograde signaling in the budding yeast Saccharomyces cerevisiae. It involves multiple factors that sense and transmit mitochondrial signals to effect changes in nuclear gene expression; these changes lead to a reconfiguration of metabolism to accommodate cells to defects in mitochondria. Analysis of regulatory factors has provided us with a mechanistic view of regulation of retrograde signaling. Here we review advances in the yeast retrograde signaling pathway and highlight its regulatory factors and regulatory mechanisms, its physiological functions, and its connection to nutrient sensing, TOR signaling, and aging.

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          Author and article information

          Journal
          Annu Rev Genet
          Annual review of genetics
          Annual Reviews
          0066-4197
          0066-4197
          2006
          : 40
          Affiliations
          [1 ] Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9148, USA. zhengchang.liu@utsouthwestern.edu
          Article
          10.1146/annurev.genet.40.110405.090613
          16771627
          90e8ca38-bd44-4370-b8ea-e36451b476ce
          History

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